Epalrestat (EPS) is the only aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. Recently, we found that EPS at near-plasma concentration increases the intracellular levels of glutathione (GSH) in rat Schwann cells. GSH plays a crucial role in protecting endothelial cells from oxidative stress, thereby preventing vascular diseases. Here we show that ...

The relationships between glucose metabolism and exopolysaccharide (EPS) production in a Lactococcus lactis strain containing the EPS gene cluster (Eps(+)) and in nonproducer strain MG5267 (Eps(-)) were characterized. The concentrations of relevant phosphorylated intermediates in EPS and cell wall biosynthetic pathways or glycolysis were determined by (31)P nuclear magnetic resonance. The conce...

BACKGROUND Encapsulating peritoneal sclerosis (EPS) commonly presents after peritoneal dialysis has been stopped, either post-transplantation (PT-EPS) or after switching to hemodialysis (classical EPS, cEPS). The aim of the present study was to investigate whether PT-EPS and cEPS differ in morphology and clinical course. METHODS In this European multicenter study we included fifty-six EPS pat...

EPS geofoam can be used to support highway bridge structures without the aid of deep foundations. The development of this technology is important to accelerate construction on soft compressible soil. EPS geofoam allows for the rapid construction of bridge foundations on such soils without the time and cost involved in installing traditional foundations. Because EPS geofoam is an extremely light...

The aim of this study was to determine the angiogenic properties of an oversulfated exopolysaccharide (OS-EPS) derived from a polysaccharide secreted by the mesophilic bacterium Alteromonas infernus. We compared the effect of this OS-EPS with that of a non-oversulfated exopolysaccharide (EPS) on human umbilical vein endothelial cell (HUVEC) proliferation, migration and differentiation induced b...

Encapsulating peritoneal sclerosis (EPS) is a serious complication of long-term peritoneal dialysis (PD). The reported incidence varies between 0.5% and 4.4% and increases with length of time on PD. Very few data are available on the epidemiology of EPS in the United States. The aim of the present study was assess the incidence of EPS in a single center in New Haven, Connecticut. In a retrospec...

BACKGROUND We developed an ethanol extract of peanut sprouts (EPS), a peanut sprout-derived natural product, which contains a high level of trans-resveratrol (176.75 µg/ml) and was shown to have potent antioxidant activity. OBJECTIVE We evaluated the potential anti-inflammatory activity of EPS by measuring its antioxidant potential in skin. METHODS The anti-inflammatory activity of EPS was ...

The aim of this study was to investigate the influence of different parameters on exopolysaccharide (EPS) production from Enterobacter cloacae subsp. dissolvens using seawater as a basal medium. For this purpose, the effect of carbon (sucrose, molasses, paraffin and sunflower oil) and nitrogen sources, NaCl concentration, incubation time, pH as well as seawater dilution or enrichment with disti...

Earnings per share (EPS) represents the profitability of a common stock and the financial performance of a particular company. Therefore, EPS is often regarded as a major indicator for investors to purchase stocks. The traditional approach is to use a conventional linear time series model for EPS prediction. However, the results would be in doubt when the forecasting problems are nonlinear. For...