In this paper, we adapt a mixture model originally developed for regression models with independent data for the more general case of correlated outcome data, which includes longitudinal data as a special case. The estimation is performed by a gener-alisation of the EM algorithm which we call the Expectation-Solution (ES) algorithm. In this ES algorithm the M-step of the EM algorithm is replace...

Purpose: Molecular deregulations underlying epithelioid sarcoma (ES) progression are poorly understood yet critically needed to develop new therapies. Epidermal growth factor receptor (EGFR) is overexpressed in ES; using preclinical models, we examined the ES EGFR role and assessed anti-ES EGFR blockade effects, alone and with mTOR inhibition. Experimental Design: EGFR and mTOR expression/activ...

In this paper we study the model risk of Expected Shortfall (ES), extending the results of Boucher et al. (2014) on model risk of Value-at-Risk (VaR). We propose a correction formula for ES based on passing three backtests. Our results show that for the DJIA index, the smallest corrections are required for the ES estimates built using GARCH models. Furthermore, the 2.5% ES requires smaller corr...

Solvent–steam mixture is a key factor in controlling the economic efficiency of the solvent-aided thermal injection process for producing bitumen in a highly viscous oil sands reservoir. This paper depicts a strategy to quickly provide trade-off operating conditions of the Expanding Solvent–Steam Assisted Gravity Drainage (ES-SAGD) process based on Pareto-optimality. Response surface models are...

Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription factors or activation of the extracellular signal-regulated kinase 1/2 (Erk1/2) pathway. Here we have ...

The rate of constitutive isoprenoid emissions from plants is driven by plant emission capacity under specified environmental conditions (ES, the emission factor) and by responsiveness of the emissions to instantaneous variations in environment. In models of isoprenoid emission, ES has been often considered as intrinsic species-specific constant invariable in time and space. Here we analyze the ...

Distinguishing between the capacity of ecosystems to generate ecosystem services (ES) and the actual use of these service (ES flow) in ES assessment and mapping is important to develop an understanding of the sustainability of ES use. This study assesses the spatial variation in ES capacity and flow in the Mediterranean small island state of Malta. The services included in this study were crop ...

Enterprise systems (ES) implementations are regarded costly, time and resource consuming and have a great impact on the organization in terms of the risks they involve and the opportunities they provide. The steering committee (SC) represents the group of individuals who is responsible for making strategic decisions throughout the ES implementation lifecycle. It is evident from recent studies t...

Exsheathing fluid (EF) and excretory-secretory products (ES) of infective third-stage cultured larvae ofOstertagia circumcincta were analysed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDSPAGE). Five and seven predominant proteins were found in the EF and ES products, respectively. Immunoblotting by sheep pre-infection serum did not react with any of the EF and ES proteins, b...