Between 1990 and 2008, air pollution emissions from U.S. manufacturing fell by 60 percent despite a substantial increase in manufacturing output. We show that these emissions reductions are primarily driven by within-product changes in emissions intensity rather than changes in output or in the composition of products produced. We then develop and estimate a quantitative model linking trade wit...

GABA receptors (GABAARs) mediate inhibition in the adult brain. These channels are heteropentamers and their ligand binding sites are localized at the β+ / α- interfaces. As expected, mutations of binding-site residues affect binding kinetics but accumulating evidence indicates that gating is also altered, although the underlying mechanisms are unclear. We investigated the impact of the hydroph...

Objective: Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that causes progressive loss of the upper and lower neurons in brain spinal cord. SOD1 was first gene linked to ALS, which more than 150 mutations throughout sequence protein have been found be associated with ALS. Methods: The drugs can interact inhibit misfolding or revert misconformation useful treatment Monomer ...

PO Box 6395, Lawrenceville, NJ 08648-0395, USA, and EMBL Hamburg Outstation, c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany The January issue of Acta Crystallographica Section F traditionally highlights the crystallization content of our journal with a cover illustration composed of the past years best in crystal photomicrographs. This year is no exception. The design is again the work our...

Between 1990 and 2008, air pollution emissions from U.S. manufacturing fell by 60 percent despite a substantial increase in manufacturing output. We show that these emissions reductions are primarily driven by within-product changes in emissions intensity rather than changes in output or in the composition of products produced. We then develop and estimate a quantitative model linking trade wit...

Huang, Ren-Qi, Zhenglan Chen, and Glenn H. Dillon. Molecular basis for modulation of recombinant 1 2 2 GABAA receptors by protons. J Neurophysiol 92: 883–894, 2004. First published March 17, 2004; 10.1152/jn.01040.2003. We have previously shown that extracellular protons inhibit recombinant and native GABAA receptors. In this report, we studied the site(s) and mechanism by which protons modulat...

Between 1990 and 2008, air pollution emissions from U.S. manufacturing fell by 60 percent despite a substantial increase in manufacturing output. We show that these emissions reductions are primarily driven by within-product changes in emissions intensity rather than changes in output or in the composition of products produced. We then develop and estimate a quantitative model linking trade wit...

4-Chlorobenzoyl-coenzyme A (4-CBA-CoA) dehalogenase catalyzes the hydrolysis of 4-CBA-CoA to 4-hydroxybenzoyl-coenzyme A (4-HBA-CoA), using the carboxylate side chain of aspartate 145 to displace the chloride from C(4) of the benzoyl ring. Previous UV-visible, Raman, and 13C NMR studies of enzyme-bound substrate analog or product ligand indicated that the environment of the enzyme active site i...

Abstract Introduction Testosterone therapy (TT) has been shown to improve libido in females with sexual dysfunction; however, utilization of TT limited part due concern for increased cardiovascular risk. Objective Our objective was assess the association major adverse cardiac events (MACE) using a large claims database. Methods A US-based database (TriNetX Diamond Network) over 200 million pati...