The broad ligand-binding characteristic of PPARbeta/delta has long hampered identification of physiologically-meaningful ligands for the receptor. The observations that the activity of PPARbeta/delta is supported by fatty acid binding protein 5 (FABP5), which directly delivers ligands from the cytosol to the receptor, suggest that bona fide PPARbeta/delta ligands both activate the receptor, and...

Fatty acid binding proteins (FABPs), in particular FABP5 and FABP7, have recently been identified by us as intracellular transporters for the endocannabinoid anandamide (AEA). Furthermore, animal studies by others have shown that elevated levels of endocannabinoids resulted in beneficial pharmacological effects on stress, pain and inflammation and also ameliorate the effects of drug withdrawal....

Fatty acid binding proteins (FABPs) are low-molecular-mass, soluble, intracellular lipid carriers. Previous studies on adipocytes from adipocyte fatty acid binding protein (A-FABP)-deficient mice have revealed that both basal and isoproterenol-stimulated lipolysis were markedly reduced (Coe et al. 1999. J. Lipid Res. 40: 967-972). Herein, we report the construction of transgenic mice overexpres...

Low-grade gliomas (LGGs) are grade III based on the WHO classification with significant genetic heterogeneity and clinical properties. Traditional histological of has been challenged by improvement molecular stratification; however, reproducibility diagnostic accuracy LGGs still remain poor. Herein, we identified fatty acid binding protein 5 (FABP5) as one most enriched genes in malignant eleva...

background: the aberrant expression of dickkopf-1 (dkk1), triose phosphate isomerase (tpi) and fatty acid binding-protein 5 (fabp5) in lung cancer tissues and their presence in secretome of lung cancer cell lines were reported. here, serum levels of these molecules in lung cancer patients were compared to those in a healthy control group. materials and methods: the patients’ group consisted of ...

In the present study cytogenetic localization of eight fatty acid binding protein genes in the pig genome was shown. BAC clones, containing sequences of selected genes (FABP1, FABP2, FABP3, FABP4, FABP5, FABP6, FABP7 and FABP8) were derived from porcine BAC libraries and mapped by FISH to porcine chromosomes (SSC) 3q12, 8q25, 6q26, 4q12, 4q12, 16q22, 1p22 and 4q12, respectively. Detailed analys...

Abstract Psoriasis is a common chronic inflammatory skin disease. One of the hallmarks psoriasis abundance neutrophil infiltration in lesions. However, detailed molecular mechanisms chemotaxis and activation remains unclear. Here we demonstrated an upregulation epidermal fatty acid binding protein (E-FABP, also known as FABP5) tissue from both human imiquimod (IMQ)-induced psoriatic mouse model...

Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and strongly correlated with tumor growth, development, metastasis. However, it unclear how the expression FABP5 host affects progression. In this study, using a lung metastasis model mice, we found that FABP5-deficient mice were more susceptible to metastasis, which accompanied by infiltration lower frequency ac...