«fed batch process»
۱۲۸۵ نتیجهReal-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes
The real-time measurement of biomass has been addressed since many years. The quantification of biomass in the induction phase of a recombinant bioprocess is not straight forward, since biological burden, caused by protein expression, can have a significant impact on the cell mor
Automated dynamic fed-batch process and media optimization for high productivity cell culture process development.
Current industry practices for large-scale mammalian cell cultures typically employ a standard platform fed-batch process with fixed volume bolus feeding. Although widely used, these processes are unable to respond to actual nutrient consumption demands from the culture, which ca
Modelling and Regularity of Nonlinear Impulsive Switching Dynamical System in Fed-Batch Culture
and Applied Analysis 3 According to the factual experiments, we make the following assumptions. H1 The concentrations of reactants are uniform in reactor, while time delay and nonuniform space distribution are ignored. H2 The feeding media includes only fixed concentrations of gl
Reliable Multi-Objective On-line Re-Optimisation Control of Batch Processes Based on Bootstrap Aggregated Neural Networks
The paper presents a reliable multi-objective re-optimisation control strategy for batch processes based on bootstrap aggregated neural networks. Bootstrap aggregated neural networks not only give better generalisation performance than single neural networks but also provide mode
Evaluation of disposable filtration systems for harvesting high cell density fed batch processes
Introduction In the underlying study we evaluated different single-use filtration systems for cell separation and harvest clarification in 1,000 L scale. A screening of different depth filters was carried out with various single-use filters from Pall, Cuno (3M), Millipore and Sar
Batch-to-Batch Iterative Learning Control of a Fed-batch Fermentation Process Using Incrementally Updated Models
Batch-to-batch iterative learning control of a fed-batch fermentation process using batchwise linearised models identified from process operation data is presented in this paper. Due to model-plant mismatches and the present of unknown disturbances, off-line calculated control po
-Amylase Production in Fed Batch Cultivation of Bacillus caldolyticus: An Interpretation of Fermentation Course Using 2-D Gel Electrophoresis
The conditions for increased production of thermostable -amylase from Bacillus caldolyticus DSM 405 were investigated. Preliminary experiments in batch shake flasks led to an optimized initial cultivation medium. Shake flask experiments in extended-batch and in fed-batch mode of
Modeling of overflow metabolism in batch and fed-batch cultures of Escherichia coli.
A dynamic model of glucose overflow metabolism in batch and fed-batch cultivations of Escherichia coli W3110 under fully aerobic conditions is presented. Simulation based on the model describes cell growth, respiration, and acetate formation as well as acetate reconsumption durin
Production of cellulase on mixtures of xylose and cellulose in a fed-batch process.
Cellulase production by the RUT-C30 mutant of the fungus Triclzoderma reesei on mixtures of xylose and cellulose was studied in a fed-batch system. An initial mixture of 30 g/L xylose and 20 g/L cellulose and an intermittent feeding rate of 5 g/L/day xylose and 15 g/L/day cellulo
Improved Ethanol Production Based on High Solids Fed- Batch Simultaneous Saccharification and Fermentation with Alkali-Pretreated Sugarcane Bagasse
Alkali-pretreated sugarcane bagasse fiber was subjected to fed-batch simultaneous saccharification and fermentation (SSF) with a prehydrolysis process to increase the solids loading and produce a high concentration of ethanol. The hydrolysis medium and yeast feeding modes were in