In handwritten text there are usually several accepted styles for forming each character. We hypothesize that in the handwriting of individuals there is a correlation among the styles used for characters, and that these correlations may be used to anticipate which styles particular writers will use for symbols that have not yet been seen. This approach may prove useful in the setting of mathema...

Communicative moves and lexical cohesion patterns (LCPs), as mounting evidence shows, are two important indicators in writing and publishing the RAs. However, the interaction between these two crucial elements and the contribution of this interaction to the failure or success of the RAs have not been given due attention to date. Having this in mind and based on a sound theoretical framework, at...

Voltage-gated calcium channels (CaVs) are large, multisubunit complexes that control cellular calcium entry. CaV pore-forming (CaValpha1) and cytoplasmic (CaVbeta) subunits associate through a high-affinity interaction between the CaValpha1 alpha interaction domain (AID) and CaVbeta alpha binding pocket (ABP). Here we analyze AID-ABP interaction thermodynamics using isothermal titration calorim...

The mechanism of denaturation of proteins by urea is explored by using all-atom microseconds molecular dynamics simulations of hen lysozyme generated on BlueGene/L. Accumulation of urea around lysozyme shows that water molecules are expelled from the first hydration shell of the protein. We observe a 2-stage penetration of the protein, with urea penetrating the hydrophobic core before water, fo...

In the title mol-ecule, C(10)H(8)ClN(3)O(2), the dihedral angle between the pyridine and pyrazole rings is 64.01 (8)°. In the crystal structure, inter-molecular O-H⋯N hydrogen bonds link mol-ecules, forming extended chains along [001]. These chains are, in turn, linked by weak inter-molecular C-H⋯O inter-actions, forming a two-dimensional network perpendicular to the b axis.