Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug-drug interaction. NAF exhibits superior efficacy but must be administered at a much higher dosage than other therapeutic drugs. We previously showed that extensive glucuronidation of N...

Recently there has been increased interest in logic programming-based default reasoning approaches which are not using negation-as-failure in their object language. Instead, default reasoning is modelled by rules and a priority relation among them. Historically the first logic in this class was Defeasible Logic. In this paper we will study its relationship to other approaches which also rely on...

A flowing afterglow discharge ion source with NaF vaporized into the flow produces the expected stable anions F-(NaF),, as well as the unusual species Na(NaF); and (NaF); (n < 17). The dominance of (NaF); suggests that it has a particularly stable structure. A fixed-frequency laser has been used to photodetach electrons from mass-selected ion beams extracted from the flowing afterglow. Photoele...

The paper proposes a τ−NAF method for scalar multiplication on Koblitz curves, which requires asymptotically 0.215m point additions in GF (2). For τ−NAF method, point quading operation (a→ a) is performed instead of point squarings. The proposed method is faster than normal τ−NAF method, which requires around m 3 point additions. However, like width w based τ−NAF methods, there is an overhead o...

Helices andaggregates of helices (chromatoid bodies) composed of ribosomelike particles appear in cysts and slow-growing trophozoites of Entamoeba invadens. We found that similar helix aggregates were formed abundantly in actively growing E. invadens trophozoites treated with a variety of direct or indirect inhibitors of protein synthesis. The inhibitor-induced helices appeared cytochemically a...

Patellofemoral pain is characterized by pain behind the kneecap and is often thought to be due to high stress at the patellofemoral joint. While we cannot measure bone stress in vivo, we can visualize bone metabolic activity using (18) F NaF PET/CT, which may be related to bone stress. Our goals were to use (18) F NaF PET/CT to evaluate whether subjects with patellofemoral pain exhibit elevated...

AIM The aim of this in vitro study was to evaluate the effects of different sodium fuoride (NaF) concentrations and pH values on the Knoop hardness (KHN), surface roughness (SR), and morphology of bovine incisors bleached with 35% hydrogen peroxide (HP). MATERIALS AND METHODS Sixty-five bovine incisors were fragmented (5 mm(2) × 2 mm) and distributed in 5 groups: Control (unbleached), Low NaF...

Prostate-specific antigen (PSA) is produced by the female breast. Prior in vitro evidence suggests that PSA expression in breast epithelial cells is regulated by androgens and progestins but not estrogens. The purpose of this study was to determine whether (a) PSA expression in breast nipple aspirate fluid (NAF) and in serum is influenced by progesterone (PG); (b) the ability to obtain NAF decr...

Many studies suggest that fluoride exposure can inhibit the activity of various enzymes and can generate free radicals, which interfere with antioxidant defence mechanisms in living systems. To further the understanding of this issue, this present study examined the effects of low-dose fluoride treatment on the activity of enzymatic antioxidant superoxide dismutase (SOD) and catalase (CAT), as ...