DNA is a strong polyelectrolyte macromolecule making metal ions (counterions) condense to cloud around the double helix. The counterions may be localized outside and inside minor major grooves of In present work, distribution condensed between inner outer regions has been studied using approaches counterion condensation theory. results have shown that number trapped should greater than 0.16 per...

In this paper, position vector of a spacelike general helix with respect to standard frame in Minkowski space E 1 are studied in terms of Frenet equations. First, a vector differential equation of third order is constructed to determine position vector of an arbitrary spacelike general helix. In terms of solution, we determine the parametric representation of the general helices from the intrin...

In this work, we deal with a classical differential geometry topic in Minkowski space-time. First, we prove that there are no timelike involutes of a time-like evolute. In the light of this result, we observed that involute curve transforms to a time-like curve when evolute is a space-like helix with a time-like principal normal. Then, we investigated relationships among Frenet-Serret apparatus...

The GXXXG motif is a frequently occurring sequence of residues that is known to favor helix-helix interactions in membrane proteins. Here we show that the GXXXG motif is also prevalent in soluble proteins whose structures have been determined. Some 152 proteins from a non-redundant PDB set contain at least one alpha-helix with the GXXXG motif, 41 +/- 9% more than expected if glycine residues we...

bioactive products from snail slime of “helix” specie have potential applications in preventing and/or treating several human diseases and in cancer diagnosis. however, the poor pharmacokinetics characteristics of these natural compounds limit their use. nanotechnology offers promising solutions for the enhanced formulation of these molecules through the synthesis of nanosized drug delivery sys...

Rhodonellum psychrophilum GCM71(T), isolated from the cold and alkaline submarine ikaite columns in the Ikka Fjord in Greenland, displays optimal growth at 5 to 10°C and pH 10. Here, we report the draft genome sequence of this strain, which may provide insight into the mechanisms of adaptation to these extreme conditions.

Helices are an essential element in defining the three-dimensional architecture of structured RNAs. While internal basepairs in a canonical helix stack on both sides, the ends of the helix stack on only one side and are exposed to the loop side, thus susceptible to fraying unless they are protected. While coaxial stacking has long been known to stabilize helix ends by directly stacking two cano...