Model selection procedures for simultaneous analysis of all single-nucleotide polymorphisms in genome-wide association studies are most suitable for making full use of the data for a complex disease study. In this paper we consider a penalized regression using the LASSO procedure and show that post-processing of the penalized-regression results with subsequent stepwise selection may lead to imp...

Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to researchers. Many existing genetic-analysis tools are not designed to handle such large data sets in a convenient manner and do not necessarily exploit the new opportunities that whole-genome data bring. To address these issues, we developed PLINK, an open-source C/C++ WGAS tool set. With PLINK, ...

We show through a simulation study how the joint analysis of data from phase I and phase II studies enhances the power of pharmacogenetic tests in pharmacokinetic (PK) studies. PK profiles were simulated under different designs along with 176 genetic markers. The null scenarios assumed no genetic effect, while under the alternative scenarios, drug clearance was associated with six genetic marke...

genetic studies were carried out on a total of 196 psychiatric patients, hospitalized in sorkhe hesar, roozbeh, cherazi and chaharom aban hospitals. out of all the patients studied, 74 were schizophrenic, 30 manic-depressive, 47 depressive (neurotic), 12, hysteric, 9 epileptic and the remainder had different psychiatric diseases and conditions such as: anxiety and phobia, scrupulousness mental ...

It is widely recognized nowadays that complex diseases are caused by, amongst the others, multiple genetic factors. The recent advent of genome-wide association study (GWA) has triggered a wave of research aimed at discovering genetic factors underlying common complex diseases. While the number of reported susceptible genetic variants is increasing steadily, the application of such findings int...

the rs2476601 (r620w, c1858t) polymorphism in ptpn22 gene has been repeatedly reported to be associated with rheumatoid arthritis (ra). the rs 2476601 is widely suggested for predictive testing and risk assessment for ra. the aim of this study was to test the possible association of this snp with ra in iranian population.a total of 872 samples (405 confirmed ra patients and 467 healthy controls...

An important task in the genetic understanding of disease is determining whether there is a significant association between a phenotype and a set of markers. This task is sometimes referred to as a group test in a genome-wide association study. Examples of this task include determining whether a set of rare variants are associated with a phenotype, and whether a set of single nucleotide polymor...