115 couples with consanguineous marriage, who had experienced reported abortions or still births either in their close relatives (3 couples) or themselves (1 couple) were exposed to genetic counseling (at the shahid akbarabadi hospital) cytogenetic studied were carried out using both conventional staining and g.t.g banding for all the cases studied. the investigation demonstrated various forms ...

ône-third of population deal with sleep disorders which might be due to social, economic or medical problems. studies on twins have indicated the role of genetic factors in these disorders. monozygotic twins have a very similar hypnogram. â higher prevalence of some sleep disorders is reported in relatives of the patients with these disorders. genes also affect sleep disorders as well as some o...

introduction: gestational diabetes mellitus (gdm) is defined as abnormal glucose tolerance that is first identified or diagnosedduring pregnancy.deiodinase d2 is essential for the local production of t3 through deiodination of triiodothyroxine (t4). several polymorphisms in d2 have been described. the single-nucleotide polymorphism (snp) in d2 thr92ala is associated with decreased enzyme activi...

background: lung cancer is considered as one of the most frequent cancers worldwide, and has been the cause of more than onemillion mortalities each year. exposure to tobacco smoke is the primary cause of most lung cancers, since it contains several thousandcompounds, including more than 50 known carcinogens. however, a small fraction of individuals who are exposed to tobacco smokedevelop lung ...

how to cite this article: houshmand m. genetic investigation of lukodystrophy in iran. iran j child neurol.autumn 2014;8;4(suppl.1):11-12.

background hereditary hemochromatosis (hh) is a very rare disease in iran and reported cases are all negative for hfe mutation. we report a family affected by severe juvenile hemochromatosis (jh) with a detailed molecular study of the family members. methods we studied a pedigree with siblings affected by juvenile hh and followed them for 3 years. microsatellite and gene sequencing analysis was...

the archaeological evidence suggests that iran has been one of the first origins of sheep domestication in the world. this study aims to investigate the genetic diversity of indigenous iranian sheep breeds using mitochondrial dna (mtdna) and to explore the evolutionary history of sheep domestication in iran. single nucleotide polymorphism (snp) markers in the control region of mtdna were used t...