conclusions our results showed that hcv genotype 4 is the most prevalent genotype in the middle east region. however, hcv genotype 1 is the most prevalent among non-arab countries in the region including turkey, iran, cyprus, and israel. context the hepatitis c virus (hcv) is classified into seven genotypes and more than 100 subtypes. the treatment regimen, duration and efficacy of hcv therapy ...

BACKGROUND Daclatasvir is an NS5A inhibitor approved for treatment of infection due to hepatitis C virus (HCV) genotypes (GTs) 1-4. To support daclatasvir use in HCV genotype 4 infection, we examined a diverse genotype 4-infected population for HCV genotype 4 subtype prevalence, NS5A polymorphisms at residues associated with daclatasvir resistance (positions 28, 30, 31, or 93), and their effect...

OBJECTIVES To assess the risk of death in relation to apolipoprotein E (APOE) genotype and to evaluate how APOE genotype interacts with dementia and with other major medical conditions to affect survival. DESIGN A 6-year prospective cohort study of dementia, APOE genotype and survival. SETTING Health maintenance organization in southern California. PARTICIPANTS One thousand eight hundred ...

Our objective was to characterize the distribution, diversity and patterns of hepatitis C virus (HCV) genotypes in the Middle East and North Africa (MENA). Source of data was a database of HCV genotype studies in MENA populated using a series of systematic literature searches. Pooled mean proportions were estimated for each genotype and by country using DerSimonian-Laird random-effects meta-ana...

Objectives: The aim of this report was to investigate the genotypes of HCV in patients on regular hemodialysis in Iraq Methods: A cross sectional study was conducted to investigate the genotypes of HCV in patients on regular hemodialysis in 7 centers across Iraq. 255 subjects with positive anti-HCV antibodies were recruited in this study. Results: To confirm the positivity, RTPCR was performe...