We examined whether selected polymorphisms in 11 candidate genes and serum levels of insulin-like growth factor I (IGF-I) help predict the presence of prostate cancer among patients prescreened with prostate-specific antigen (PSA) and digital rectal exam (DRE). We studied 1031 consecutive men who underwent one or more prostate biopsies because of an elevated PSA level (>4 ng/ml) or an abnormal ...

BACKGROUND Polymorphisms of glutathione S-transferases (GSTs) are linked to skin cancer, but data on their association with solar keratosis (SK) are few and conflicting. AIM To verify the possible association between the development of SK and the 'null' GSTM1 and/or T1 genotype. METHODS Analysis of the GSTM1 and T1 genotype of 33 subjects with ≥3 solar keratoses and of 150 controls, before ...

Genetic variations in the activity of xenobiotic enzymes may predict susceptibility to multiple myeloma (MM). In a case-control study, 90 Australian Caucasians with MM had significantly higher incidences of GST T1 null, PON1 BB and NAT2 slow acetylation genotypes, but no difference in polymorphism frequencies for GST M1, NAT1, and CYP1A1 when compared to 205 controls.

Background: Cellular level of enzyme activity can serve as a reliable biomarker in the event of environmental/chemical insults. Objectives: The present study investigated time-dependent alterations of erythrocyte glutathione S-transferase (Ery-GST) activity of non-malarious guinea pigs (Cavia tschudii) administered with pyrimethamine/sulfadoxine and artemether/lumefantrine combination therapies...

Objectives: Glutathione S-transferase (GST) polymorphism may play a role in the etiology of type 1 diabetes, as GST is involved to detoxification reactive oxygen radicals and synthesis proinflammatory mediators. Genetic polymorphisms renin-angiotensin aldosterone system, including angiotensin converting enzyme (ACE) gene insertion-deletion (I/D) polymorphism, can affect progression diabetes dia...

A haloenol lactone derivative has been synthesized and found to be an isozyme-selective and active site-directed inactivator of glutathione S-transferase (GST). Preincubation of the haloenol lactone (100 microM) with murine Alpha, Mu, or Pi GST isozyme (1.0 microM) at pH 6.5, 37 degrees C resulted in time-dependent loss of enzyme activity with highly selective inhibition of the Pi isozyme (t1/2...

Previous research suggests the association of glutathione S-transferase (GST) gene polymorphisms or diet, but no interactions between these factors in atopic dermatitis (AD). We conducted a community-based case-control study including 194 AD and 244 matched non-AD preschoolers. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) present/null genotypes were evaluated uisng a multiplex PCR method...

It has been evident that Glutathione S-transferase (GST) gene deficiency may contribute to the development of asthma. Therefore, we aimed to assess the association of GSTT1 and GSTM1 deficiency with passive maternal smoking (MS) during pregnancy with asthma in north Indian children. It was a hospital based case-control study, 175 bronchial asthma cases and 175 controls, aged 1 year -15 years we...

Human glutathione transferases (GSTs) from Alpha (A), Mu (M) and Theta (T) classes exhibited glutathione peroxidase activity towards phospholipid hydroperoxide. The specific activities are in the order: GST A1-1>GST T1-1>GST M1-1>GST A2-2>GST A4-4. Using a specific and sensitive HPLC method, specific activities towards the phospholipid hydroperoxide,1-palmitoyl-2-(13-hydroper oxy-cis-9, trans-1...