the aim of this study is to determine whether there is a role of podoplanin and glutathione s-transferases t1 (gst-t1) expression in laryngeal squamous cell carcinoma. the study was completed with 33 patients and gene expression analysis was performed by qrt–pcr. the podoplanin and gst-t1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryn...

The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma. The study was completed with 33 patients and gene expression analysis was performed by qRT–PCR. The podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of lar...

GST (glutathione transferase) T1-1 plays an important role in the biotransformation of halogenated alkanes, which are used in large quantities as solvents and occur as environmental pollutants. Many reactions that are catalysed by GST T1-1 qualify as detoxification processes, but some reactions with dihalogenated alkanes lead to reactive products more toxic than the substrates. Murine GST T1-1 ...

background cellular level of enzyme activity can serve as a reliable biomarker in the event of environmental/chemical insults. objectives the present study investigated time-dependent alterations of erythrocyte glutathione s-transferase (ery-gst) activity of non-malarious guinea pigs (cavia tschudii) administered with pyrimethamine/sulfadoxine and artemether/lumefantrine combination therapies. ...

OBJECTIVE Oxidative stress may be an important pathogenic mechanism in the obesity and metabolic syndrome. The aims of this study was to assess the possible association between the oxidative stress related Glutathione S-Transferase genes (GST-M1, GST-T1, and GST-P1) variants and the olanzapine-induced weight gain in Korean schizophrenic patients. METHODS We categorized 78 schizophrenic patien...

Gastric marginal zone lymphoma (GMZL) is strongly associated with Helicobacter pylori infection, which induces a chronic inflammatory response. Inflammation can result in DNA damage related to its severity, the cellular antioxidant capacity, and the integrity of DNA repair mechanisms. Interleukin-1 (IL-1) polymorphisms have been shown to be important mediators of inflammation, while glutathione...

BACKGROUND Although smoking is the major causal factor in the development of chronic obstructive pulmonary disease (COPD), only 10-20% of chronic heavy cigarette smokers develop symptomatic COPD which suggests the presence of genetic susceptibility. This genetic susceptibility to COPD might depend on variations in enzyme activities that detoxify cigarette smoke products such as microsomal epoxi...