Natural killer (NK) cells are potent immune effector cells capable of mediating antitumor responses. Thus, during immunoediting, tumor cell populations evolve strategies to escape NK-cell–mediated recognition. In this study, we report a novel mechanism of immune escape involving tumor cell shedding of B7-H6, a ligand for the activating receptor NKp30 that mediates NK-cell binding and NK-cell–me...

Intraand inter-line transfers of blastocysts were performed between two lines of mice selected for high (H6) and low (L6) body weight at 6 weeks of age. A greater percentage of L6 blastocysts survived to term than did H6 blastocysts (7\m=.\8%,P < 0\m=.\01)and more L6 recipients littered than did the H6 recipients (19\m=.\7%,P < 0\m=.\01).A greater percentage of the mice born to the L6 recipient...

Let Eq : Y 2 + XY = X3 + h4X + h6 be the Tate curve with canonical differential, ω = dX/(2Y + X). If the characteristic is p > 0, then the Hasse invariant, H, of the pair (Eq, ω) should equal one. If p > 3, then calculation of H leads to a nontrivial separable relation between the coefficients h4 and h6. If p = 2 or p = 3, Thakur related h4 and h6 via elementary methods and an identity of Raman...

Natural killer (NK) cells are lymphocytes of the innate immune system that participate in the elimination of tumor cells. In humans, the activating natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 play a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes B7-H6, a member of the B7 family which is expressed on tumor, but not healthy, cells. To understand the basis for ...

The effects of amiloride, a reported inhibitor of serum-stimulated sodium influx, were tested on tumor growth, tumor cell proliferation, and intracellular element content of cancer cells in vivo. We have shown previously that cancer cells have high intranuclear levels of sodium compared to those of their normal counterpart cells and have postulated that such a high level of sodium may be involv...

It had been suggested that the flagella of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) might contribute to host colonization. In this study, we set out to investigate the adhesive properties of H7 and H6 flagella. We studied the abilities of EHEC EDL933 (O157:H7) and EPEC E2348/69 (O127:H6) flagella to bind to bovine mucus, host proteins such as mucins, and ext...

BACKGROUND AND AIMS Previous work conducted by our group has shown that the accumulation of hepatic natural killer (NK) cells and the up-regulation of natural cytotoxicity receptors (NKP30 and NKP46) on NK cells from patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) were correlated with disease progression in HBV-ACLF. The natural cytotoxicity receptors expressed...

Planar chiral h6-arene chromium(0) complexes are finding increasing application in the synthesis of enantioenriched compounds by serving as enantiopure starting materials or ligands for catalytic asymmetric processes.[1,2] Whereas early methods of generating enantiopure 1,2-disubstituted h6-arene chromium(0) complexes relied on resolution of racemates,[3] many methods have been developed recent...

Cotton (Gossypium hirsutum L.) mRNA (H6) is expressed predominantly in fiber cells and is present during early primary cell wall formation. However, H6 protein is found to accumulate during later stages, when active secondary cell wall formation occurs, indicating possible regulation at the translational level and function in the secondary cell wall assembly. The nucleotide-derived amino acid s...

The effects of amiloride, a reported inhibitor of serum-stim ulated sodium influx, were tested on tumor growth, tumor cell proliferation, and intracellular element content of cancer cells in vivo. We have shown previously that cancer cells have high intranuclear levels of sodium compared to those of their normal counterpart cells and have postulated that such a high level of sodium may be invol...