Heparin-induced thrombocytopenia (HIT) is characterized clinically by thrombocytopenia, hypercoagulability, and increased thrombosis risk, serologically platelet-activating anti-platelet factor 4 (PF4)/heparin antibodies. Heparin-“induced” acknowledges that HIT usually triggered a proximate immunizing exposure to heparin. However, certain non-heparin medications (pentosan polysulfate, hypersulf...

Heparin was isolated from whole clam tissue Marcia opima . Purification of multimilligram quantities of heparin from this tissue sample permitted a thorough examination of its anticoagulant activity characterization, which was partially purified by fractionation by anion exchange chromatography using DEAE cellulose column. The isolated crude and partially purified fractionated sample showed me...

abstract background: thrombosis will occur due to contact of blood with unepithelialized surfaces after vascular clamping and also blood stasis during vascular surgery. heparin is administered to prevent thrombosis. the aptt test is used for assurance of the anticoagulative effect of heparin. at the end of the operation heparin is neutralized by protamine sulfate in some centers. in this study ...

results the infusion group had a lower plasma pai-1 level compared to the subcutaneous group at day 7 (11.3 ± 1.6 vs. 16.5 ± 4.2; p = 0.003). the urinary ngal level was lower in the infusion group at day 2 (131.3 ± 11.9 vs. 151.2 ± 20.6; p = 0.014); however, at day 7 the ngal level was decreased in the subcutaneous group as much as the infusion group and there was no significant difference betw...

background: fatty acids are an important source of energy for muscle contraction, particularly during longtime exercise. the objective of this clinical trail study was to determination effect of heparin infusion on lipids metabolism during submaximal exercise. methods: forty boy students performed astrand ergometery protocol for 20-minute on cycle ergometer in two separate occasions. stage1 wit...

Objective: Heparin and enoxaparin possess anti-inflammatory properties. We compared the effects of these drugs on inflammatory biomarkers in patients with ST-segment Elevated Myocardial Infarction (STEMI). Method: Thirty four patients with STEMI randomly separated in two groups and received standard doses of heparin and enoxaparin. The serum concentration of Serum Amyloid A (SAA), C-Reactive Pr...

Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug effect from unfractionated or low-molecular weight heparin that results in and potentially catastrophic thrombosis. HIT occurs due to the development of platelet-activating antibodies against multimolecular complexes platelet factor 4 (PF4) heparin. Given frequency use among hospitalized patients, calculation 4Ts Score re...