background: glues are strong, liquid adhesive derived from animal tissues. it has been shown that glue sniffing is associated with demyelinating polyneuropathy. the low molecular weight agents which cause occupational lung disease have generally included the isocyanates exposure to which could result in asthma among workers. toluene is also used widely in glue and adhesive industry and househol...

The levels of hippuric acid in the urine of people exposed to toluene vapour were measured by paper chromatography, direct colorimetry, high performance liquid chromatography and gas chromatography. The control was a similar group not exposed to toluene vapour. The values were analyzed statistically, conversion equations calculated, and the propriety of these equation discussed. Since the three...

background: toluene is a harmful substance still being used as a solvent and catalyst in many industries that can increase the level of urinary hippuric acid (uha). this study was designed to examine the level of toluene and uha among workers of industrial site in seven companies in sidoarjo, indonesia and to analyze the risk factors for abnormal uha. methods: this study was an analytical cross...

The extensive investigations on the conjugation of benzoic acid, since Wohler’s discovery in 1824 of the synthesis of hippuric acid by the animal, have failed to furnish a comprehensive and definite concept of the metabolic and chemical changes taking place when benzoic acid is introduced into the organism. No attempt has ever been made to explain why man eliminates benzoic acid almost complete...

In the previous paper (Jones & Elliott, 1959) it was shown that rat-kidney mitochondria are able to synthesize nicotinuric acid from nicotinic acid and glycine in the presence of fumarate and adenosine triphosphate (ATP). These experiments showed that nicotinuric acid synthesis is dependent upon a suitable source of energy, but did not give any other indications of the mechanism of the reaction...

The question of the extent of the ability of the human organism to detoxicate benzoic acid by conjugation with glycocoll and elimination as hippuric acid in the urine has frequently been raised. Lewinsk? observed in the urine of men to whom 12 to 20 grams of benzoic acid had been given in small doses during t,he course of twelve hours, neither free benzoic acid nor benzoyl glycuronates. With la...

The fate of 14C-benzylamine after oral administration as the hydrochloride has been investigated in two male volunteers. Over 98% of the administered radiolabel was excreted in the urine as 14C-hippuric acid within 24 hours. The rate of urinary hippuric acid excretion was extremely rapid, with more than 90% of the dose excreted after three hours.

This assay of angiotensin-converting enzyme is based on release of hippuric acid from a synthetic tripeptide, hippuryl-L-histidyl-L-leucine. Hippuric acid is separated and quantitated on a reversed-phase column under conditions similar to those used for assay of theophylline and acetaminophen. The method is rapid and free from interferences.

The performance of amino acids and carboxylic acids of biological importance on the corrosion of mild steel and copper in sodium chloridesolutionswas investigated. Manyofthe amino acidsare inhibitive. Aspartic acid, cysteine, cystine, threonine and histidine enhance the corrosion of mild steel. For copper, however, all t he compounds except 4-amino n-butyric acid and hippuric acid, promote corr...