Histamine H1 receptors mediate activation of phospholipase C, with subsequent increases in cytosolic Ca2+ concentration ([Ca2+]i), and H2 receptors mediate accumulation of cAMP. HL-60 promyelocytes possess H2 receptors, but it is not known whether these cells also possess H1 receptors. We studied the effects of histamine on [Ca2+]i and the functional importance of histamine receptors in HL-60 p...

Mol. Nutr. Food Res. 2021, 65, 2100100 DOI: 10.1002/mnfr.202100100 Turmeric (Curcuma longa) has sleep-promoting effects in mice through blockade of histamine H1 receptors. This is reported by Suengmok Cho and co-workers article number 2100100.

In a previous study, the relaxant and anticholinergic (functional antagonism) effects of Bunium persicum (B. persicum ) have been demonstrated on guinea pig tracheal chains. To elucidate the other mechanisms responsible for this relaxant effect, the inhibitory effect of this plant on histamine H1 receptors was examined in this study. The antihistaminic effects of aqueous and macerated extracts,...

In the present study, the effects of intracerebroventricular (ICV) administration of normal saline (control), histamine, mepyramine (a histamine H1-receptor antagonist) and ranitidine (a histamine H2-receptor antagonist) were investigated on the formalin-induced pain in rabbits. Subcutaneous (SC) injection of a formalin (100 μl, 5%) solution into the ventral surface of the right hind paw was pe...

objective: the nucleus accumbens (nac) receive histaminergic neurons from tuberomammillary nuclei. there are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety. the aim of the present study was to assess whether the histaminergic system of the nac is involved in anxiety-related behaviors. methods:   rats   were   anesthet...

Dr. Iwan de Esch is an assistant professor and Prof. Rob Leurs is full professor and head of the Division of Medicinal Chemistry of the Leiden/Amsterdam Center of Drug Research (LACDR), VU University Amsterdam, The Netherlands. Since the seventies, histamine receptor research has been one of the traditional themes of the division. Molecular understanding of ligand-receptor interaction is obtain...

The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 μl, 2.5 %) in the ventral surface of right hind paw produced a biphasic pattern (first phase: 0-5 min and second phase: 15 - 60 min) of licking/biting an...

Histamine receptors have been demonstrated on lymphocyte membranes by a variety of techniques. We now report a method that allows for the flow cytometric analysis of histamine receptors on human peripheral T cells. Histamine is conjugated to fluoresceinated human albumin by the coupling agent ECDI. This conjugated histamine compound (FHA-his) binds to approximately 45% of T cells. Fluoresceinat...