Outbred Hartley strain guinea pigs capable of responding immunologically to 2,4-dinitrophenylated poly-L-lysine were shown to display a histocompatibility specificity in common with inbred strain 2 guinea pigs. This histocompatibility specificity was not detected in guinea pigs unable to respond immunologically to DNP-PLL. The result suggests that the poly-L-lysine specific immune response gene...

OBJECTIVE To analyze major histocompatibility complex expression in the muscle fibers of juvenile and adult dermatomyositis. METHOD In total, 28 untreated adult dermatomyositis patients, 28 juvenile dermatomyositis patients (Bohan and Peter's criteria) and a control group consisting of four dystrophic and five Pompe's disease patients were analyzed. Routine histological and immunohistochemica...

The HLA Technologist and Director Certification Program for Histocompatibility Testing of the Japanese Society Immunogenetics (JSHI) offers various programs training opportunities members to be certified as expert. Here we will make comment on difficult questions from past paper tests help your study. In addition, medical ethics issues mentioned provide a learning opportunity.

Alloimmune specificity and histocompatibility, driven by genetic polymorphism, are ancient determinants of self-/non-self-recognition. Recent molecular genetic evidence has revealed an allodeterminant in the cnidarian Hydractinia that consistently predicts histocompatibility reactions.