background: in this study, we evaluated the incidence of apoptosis at the ultrastructural levels and expression of some apoptosis-related genes in vitrified human ovarian tissue just after warming. methods: human ovarian tissue biopsies from 23 women after caesarean section were transported to the laboratory within 2 hours, and then they were cut into small pieces. some pieces were vitrified an...

background and aims: ovarian cancer is one of most common causes of cancer related women's mortalities. human papilloma virus is a known factor concerning cervical cancer but its role in causing ovarian cancer is not yet verified. a few studies also identified hpv dna in ovarian carcinoma tissues. however, some studies did not detect hpv dna in ovarian carcinoma tissues. in this article, we inv...

Background Ovarian tissue cryopreservation is an option for patients who require immediate gonagonadotoxic treatment of cancers. when there is insufficient time to conduct ovulation induction This procedure can be used in patients with genetic mutations with a high risk for premature ovarian failure.This strategy is the only option for fertility preservation in prepubertal girls or in women who...

Background: The aim of this study was to evaluate the efficacy of a vitrification protocol developed by our group to cryopreserve ovarian tissue. For this, we used ovaries from non-human primates in order to have an animal model close to the clinical setting. Materials and Methods: Ovarian biopsies from five adult baboons were vitrified, warmed and autografted. After five months, follicle survi...

the transcriptional factor sox2 regulates the expression of some of the developmental genes, which are essential for the maintenance of pluripotency of stem cells. sox2 also expresses in the female gamete during folliculogenesis, but its role remains ambiguous. the aim of this study was to investigate the expression of sox2 in the mice ovarian tissue during different stage of estrous cycle. adu...

the transcriptional factor oct4 regulates pluripotency of stem cells and has an important role during oocyte growth. whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. therefore, this study was aimed to investigate the expression patterns of oct4 in mouse ovaries during the normal estrous cycle. adult national medical research institute mice were classified as...

Background: With all the recent advances in cancer treatments, many young cancer patients find themselves facing the prospect of losing their fertility after aggressive chemotherapy or radiotherapy. Cryopreservation of ovarian cortical tissue has emerged as a potential option to restore fertility in these young women. Materials and Methods: Because autotransplantation of cryopreserved ovarian c...

Background and Aims: Ovarian cancer is one of most common causes of cancer related women's mortalities. Human papilloma virus is a known factor concerning cervical cancer but its role in causing ovarian cancer is not yet verified. A few studies also identified HPV DNA in ovarian carcinoma tissues. However, some studies did not detect HPV DNA in ovarian carcinoma tissues. In this articl...

BACKGROUND Ovarian tissue cryopreservation is a technique for fertility preservation addressed to prepubertal girls or to patients for whom no ovarian stimulation is possible before initiation of gonadotoxic treatments. Autotransplantation of frozen-thawed ovarian tissue is the only available option for reuse but presents some limitations: ischemic tissue damages post-transplant and reintroduct...