Fanconi anemia complementation group (FANC) proteins constitute the Fanconi Anemia (FA)/BRCA pathway that is activated in response to DNA interstrand crosslinks (ICLs). We previously performed yeast two-hybrid screening to identify novel FANC-interacting proteins and discovered that the alpha subunit of AMP-activated protein kinase (AMPKα1) was a candidate binding partner of the FANCG protein, ...

We present a novel 3D hybrid assembly of a polymer microfluidic chip with polycarbonate track-etched membrane (PCTEM) enabling membrane-supported cell culture. Two chip designs have been developed to establish either diffusive or convective reagent delivery using the integrated PCTEM. While it is well suited to a range of cell-based assays, we specifically employ this platform for the screening...

Medium voltage hybrid bridge multilevel converter (MMC) usually has a lower number of links. Therefore, the traditional Nearest Level Modulation (NLM) method problems low equivalent switching frequency and poor output quality. And Carrier Phase-shifted Pulse Width (CPS-PWM) modulation such as difficulty in control, redundant configuration, large amount calculation. In response to above problems...

Considering both the DC fault ride-through (FRT) and lightweight requirements of modular multilevel converter (MMC), this paper proposes a hybrid arm-multiplexing (HAM-MMC). The phase leg proposed MMC topology is divided into upper, middle, lower arms, configured with full-bridge submodules (FBSMs), half-bridge (HBSMs), FBSMs, respectively. time-division multiplexing middle arms between upper a...

Background: Lymphocytes of Fanconi anemia (FA) show an increased sensitivity to the alkylating agents such as mitomycin C (MMC), but their responses to gamma-irradiation is controversial. The extent of DNA damage in leukocytes of FA patients following irradiation and MMC treatment was studied at cellular and single chromosome level. Methods: DNA damage induced by gamma-rays and MMC was measure...

Modular Multilevel Converter (MMC) secured its place in applications where high reliability, efficiency and effortless voltage/power scalability are of paramount importance. Without compromising these benefits, this paper proposes a novel control appropriate design approach for Hybrid-MMC topology, comprising mix Full-Bridge HalfBridge submodules converter branches, as grid-side stage back-to-b...

Modular multilevel converter (MMC) is adopted mainly for high voltage applications with many power blocks per arm. Before commissioning a large-scale MMC application, it vital to simulate and study internal system-level dynamics. However, challenging an SMs in EMT simulation tools due time computation burden. Therefore, several simplified modeling techniques are proposed reduce the challenges. ...

The circuit topology of a submodule (SM) in an modular multilevel converter (MMC) defines many the functionalities complete power electronics conversion system and specific applications that MMC configuration can support. Most prominent among all for is its use high-voltage direct current (HVDC) transmission systems multiterminal dc grids. aim paper to provide comprehensive review classificatio...

Regenerative braking is presented in many electric traction applications such as electric and hybrid vehicles, lifts and railway. The regenerated energy can be stored for future use, increasing the efficiency of the system. This paper outlines the benefits of the MMC (modular multilevel converter) in front of the cascaded or series connection of converters to achieve high voltage from low volta...