introduction: ghrelin is an endogenous peptide that has diverse functions in the body. one of the newly recognized roles of this peptide is its antiapoptotic effect. however, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. this study will examine the effect of ghrelin treatment on bax-bcl-2 gene expression in the kidney of chronic hypoxic rats. m...

introduction: [61cu]diacetyl-bis(n4-methylthiosemicarbazone) ([61cu]atsm) is a well-established hypoxia imaging tracer with simple production and significant specifity. in this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. methods: [61cu]atsm was prepared using atsm ligand and [61cu]cuoac followed by i.v. administration and imaging studi...

during the past two decades, a variety of serum or cerebrospinal fluid (csf) biochemical markers in daily clinical practice have been recommended to diagnose and monitor diverse diseases or pathologic situations. it will be essential to develop a panel of biomarkers, to be suitable for evaluation of treatment efficacy, representing distinct phases of injury and recovery and consider the tempora...

objective: asphyxia  is  a  major  cause  of  acute  mortality  and  chronic  neurologic  disability  in  neonates. we sought to  define  the  predictive  values  of  serum  concentrations  of  interleukin-1β  in  newborns  with perinatal asphyxia to see if there is a relation between interleukin-1β (il-1β) levels to the short term neurological deficit.  methods: this was a prospective (case-co...

Adaptation to interval normobaric hypoxia has been demonstrated to provide beneficial results in a wide spectrum of diseases and health-related conditions including: primary hypercholesterolemia, essential hypertension, ischemic heart disease (stable angina of effort and rehabilitation after myocardial infarction), neurocirculatory asthenia, idiopathic stress disorders of cardiac rhythm, bronch...

how to cite this article: inaloo s, katibeh p, ghasemof m. cerebral palsy in 1-12 year old children in southern iran. iran j child neurol. winter 2016; 10(1):35-41. abstract objective cerebral palsy (cp) is a non-progressive cns disorder due to an insult to the growing brain, usually occurring in the first two years of life. during the recent years, its etiology has been changed; perinatal and ...

Background: The rationale was to develop an ablation approach to destroy regions of tumor resistant to radiation and thus reduce the time required for whole tumor ablation, while improving overall tumor control after radiotherapy. Materials and Methods: The system is composed of a micro positron emission tomography (mPET), 7T magnetic resonance imaging (MRI), and a customized MRI-compatible foc...

introduction: pro-inflammatory chemokines and cytokines   such as mcp-1 and il6 can activate microglial cells that has found in some neuro-inflammatory disorders. hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. we aimed to investigate the anti-hypoxic effects of different doses of some gabaergic agents. materials and methods: we randomly divided 150 mic...