These studies were conducted to investigate the potential use of a flow cytometric analysis method for the identification and differentiation of chemicals with the capacity to induce irritation, IgE- or T cell-mediated hypersensitivity responses. An initial study investigated the ability of equally sensitizing concentrations (determined by local lymph node assay) of IgE-mediated (Toluene Diisoc...

Usage of cancer chemotherapeutics drugs can be associated with adverse drug reactions. When IgE-mediated drug reactions are formed following administration of a chemotherapeutic drug that is a drug of choice, drug desensitization protocols can be helpful. Hypersensitivity reactions can be allergic or nonallergic, but the clinical manifestations are similar. Rapid drug desensitization (RDD) is e...

PURPOSE Cefaclor is widely prescribed for various infectious diseases. As its consumption increases, the number of hypersensitivity reactions to cefaclor has increased. This study aimed to evaluate the immunologic findings of immediate hypersensitivity to cefaclor. MATERIALS AND METHODS We enrolled 47 patients with immediate hypersensitivity to cefaclor from Ajou University Hospital and Asan ...

patients. Methods: A cross-sectional study with a questionnaire for adverse drug reactions based on European Network for Drug Allergy (ENDA) was performed. Hospitalized patients older than 12 years of age were included. Results: A total of 150 patients were studied, 84 being female. Their ages ranged from 14 to 94 years, with an average of 55 years. The average number of medications per patient...

patients. Methods: A cross-sectional study with a questionnaire for adverse drug reactions based on European Network for Drug Allergy (ENDA) was performed. Hospitalized patients older than 12 years of age were included. Results: A total of 150 patients were studied, 84 being female. Their ages ranged from 14 to 94 years, with an average of 55 years. The average number of medications per patient...

patients. Methods: A cross-sectional study with a questionnaire for adverse drug reactions based on European Network for Drug Allergy (ENDA) was performed. Hospitalized patients older than 12 years of age were included. Results: A total of 150 patients were studied, 84 being female. Their ages ranged from 14 to 94 years, with an average of 55 years. The average number of medications per patient...

d m a a r a d i p C s HE HUMAN IMMUNE SYSTEM PROTECTS US AGAINST many diseases, but when activated inappropriately and excessively, a detrimental hypersensitivity reacion can occur. Gell and Coombs described 4 types of mmunologically mediated hypersensitivity reactions. In ommon clinical practice, the term allergy is used to refer o a wide variety of reactions. In actuality, allergy refers to t...

Approximately 60% of perioperative anaphylactic reactions are thought to be immunoglobulin IgE mediated, whereas 40% are thought to be non-IgE mediated hypersensitivity reactions (both considered non-dose-related type B adverse drug reactions). In both cases, symptoms are elicited by mast cell degranulation. Also, pharmacological reactions to drugs (type A, dose-related) may sometimes mimic sym...

Food protein-induced enterocolitis syndrome (FPIES) is a potentially severe non-IgE-mediated food allergy usually caused by cow's milk or soy, and more rarely by solid foods such as rice, oats, barley, chicken, turkey, egg white, green peas and peanuts. In children with FPIES, the presence of specific IgE antibodies to the causative food, either at presentation or during follow-up, defines an "...

background: several studies reported the clinical features of ige-mediated hypersensitivity after ingestion of melon. melon allergy is a common ige-mediated fruit allergy in iran. this prompted us to investigate immunochemical and molecular properties of the major allergen in melon fruit, to compare the ige-binding capacity of the natural protein with the recombinant allergen, and to determine ...