The computer analysis of relations between molecular structures and their biological activity using fragmentbased methods is very useful to draw conclusions for the understanding of drug action and for the development of more efficient non-toxic drug candidates. We used the computer system SARD-21 (Structure Activity Relationship & Design) to investigate common structural features (fragments an...

Nervous and immune system interact through many different messenger substances such as neurotransmitters, cytokines or neuropeptides. For instance, neuropeptides are capable of affecting the metabolism of cells belonging to the immune system. Conversely, cytokines such as tumor necrosis factor (TNF)-alpha, interferon (IFN)-alpha and IFN-gamma, contribute to the receptor resistance of neuropepti...

It is estimated that 80% of people in developing countries are completely dependent on traditional and folk medicines for their health care. The contribution of medicinal plants and natural products as drugs or as sources of useful drugs in medicine is unquestionable. There are many reports of medicinal plants capable of interfering with the pathophysiological processes in inflammation. Plant e...