Objective(s) Celecoxib acts through both COX-2-dependent and -independent pathways. According to the paradoxical effect of NO on the inflammatory and nociceptive signal processing, the present study designed to evaluate the probable contribution of NO in the analgesic and anti-inflammatory properties of celecoxib. Materials and Methods Different intensities of inflammatory pain were induced ...

Objective(s):Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. Anti-inflammatory effects of venlafaxine a...

the effect of blood glucose level changes induced by 24h food deprivation and intraperitoneal (ip) injection of insulin (2iu/kg) and glucose (2gr/kg) was investigated on the pain induced by intraplantar (ipl) injection of formalin (20ml , 5%) in mice. blood glucose level changes were determined by blood sampling from the apex of the tail of mice. ip injection of insulin and 24h food deprivation...

background: rheumatoid arthritis is a type of inflammatory pain and is an autoimmune and chronic inflammatory disease which can lead to hyperalgesia, edema and decreased motor activity in affected area. mesenchymal stem cells conditioned medium (msc-cm) has anti-inflammatory mediators which can regulate the immune responses, alleviate inflammatory symptoms and has a paracrine effects too. the a...

objectives: the study was carried out to assess the analgesic, anti-inflammatory, and cns depressant activity of the methanolic extract of  the lawsonia inermis barks(melib). materials and methods: anti-inflammatory effects of mebli were studied using carrageenan-induced inflammatory method at the dose of 300 and 500 mg/kg b.wt., p.o. analgesic activity was measured using acetic acid-induced wr...

programmed cell death is a highly regulated form of cell death, mostly distinguished by the activation of a family of cystein-aspartate proteases (caspases) that cleave various proteins resulting in morphological and biochemical changes characteristic of this form of cell death. several recent studies have addressed the role of programmed cell death in inflammatory and chronic pain states. casp...

Pain is a complex entity that can be described in several dimensions, such as, acute pain and chronic pain, characterized by its duration. After the tissue injury, activation of sensory nervous occurs from where different pro-inflammatory mediators are released with consequent nociceptive transmission characterizes genesis inflammatory pain. The main objective this study was to review role opio...

While sensory fibres normally respond to a range of physical and chemical stimuli their activity and metabolism are profoundly altered by a variety of mediators generated by tissue injury and inflammation. These include substances produced by damaged tissue, substances of vascular origin as well as substances released by afferent fibres themselves, sympathetic fibres and various immune cells. T...

Resolvins are a group of molecules derived from omega-3 fatty acids. They are part of a biochemical program that allows inflamed tissues to return to homeostasis once the need for the inflammatory response is over. Resolvins act in very low dose ranges in vitro and in vivo. New data suggest that they might have the potential to become very potent analgesic drugs in inflammatory pain.