conclusions: we determined a significant higher frequency of protein s deficiency in patients with rpl compared with controls. but the frequency of protein c deficiency and the frequency of two common thrombophilic mutations (factor v leiden and prothrombin g20210a), were not significantly different between patients with recurrent miscarriage and healthy women. results: the mean functional acti...

In the immune system, many tolerance checkpoints exist to prevent self-antigens from stimulating the relentless growth of self-reactive B and T lymphocytes. The genes and molecular pathways underpinning these checkpoints overlap with those involved in tumor suppression. As with an inherited predisposition to cancer, inherited defects in self-tolerance genes typically precipitate autoimmune dise...

Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. Case Report: Herein, we present a case of fungal infection in a girl wi...

Background: Hemophagocytic lymphohistiocytosis (HLH) is an immune system disorder characterized by uncontrolled hyper-inflammation owing to hypercytokinemia from the activated but ineffective cytotoxic cells. Establishing a correct diagnosis for HLH patients due to the similarity of this disease with other conditions like malignant lymphoma and leukemia and similarity among its two forms is dif...

hand eczema is a common distressing skin problem. it is an immune reaction to haptens. thus, substances that inhibit immune system can be effective in the treatment of hand eczema. in this study, topical fumaric acid 5% cream is compared with topical steroid in the treatment of hand eczema. patients with hand eczema were randomly divided into two groups. one group received fumaric acid 5% in a ...

today, the intractions of the immune system of the immune system, nutrition, and nervous system are one of the main research areas of interest in immunology and disease treatment. due to changes in the mood, behavior, and diet of an individual during fasting period, the body's internal homeostasis is affected. the aim of the present study was to evaluate the effects of ramadan fasting on l...

mast cells are a heterogeneous population of granulocytic cells in the immune system. mast cell granules contain numerous mediators, including neurotransmitters, cytokines, chemokines and lipid-derived factors. in addition to their well-known role in immune inflammation, the presence of mast cells in the meninges and perivascular space in the central nervous system points to their role in brain...

the pollutants due to effect on the immune system of fish increase fish sensitivity to pathogens. diazinon is one of the most used organophosphates pesticide in many agricultural areas. this study aimed to evaluate the effect of diazinon on the immune system of rainbow trout ( oncorhynchus mykiss ) and application of milk thistle plant, vitis vinifera extract to reduce the adverse effects of th...