Two subsequent different types of bone formation, we respectively named static osteogenesis (SO) and dynamic osteogenesis (DO), were observed in intramembranous ossification centers of newborn rabbits and chick embryos as well as during bone repair. In all cases the onset of intramembranous ossification is characterized by the appearance, around the vessels, of pluristratified cords of unexpect...

Assessing modes of skeletal repair is essential for developing therapies to be used clinically to treat fractures. Mechanical stability plays a large role in healing of bone injuries. In the worst-case scenario mechanical instability can lead to delayed or non-union in humans. However, motion can also stimulate the healing process. In fractures that have motion cartilage forms to stabilize the ...

Several growth factors are expressed in distinct temporal and spatial patterns during fracture repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of its ability to induce neovascularization (angiogenesis). To determine whether VEGF is required for bone repair, we inhibited VEGF activity during secondary bone healing via a cartilage intermediate (endoch...

with delayed intramembranous ossification and abnormal postaxial endochondral bone formation. The observed male to male transmission strongly suggests autosomal dominant inheritance. While there is some overlap of these features with previously reported genetic conditions, none exhibits delay in intramembranous ossification and most involve other organ systems unaVected in this family. This con...

by Holly E. Weiss The current gold standard for bone repair, autologous bone graft, is inherently costly and destructive to the site from which the tissue is harvested. Moreover, the amount of available donor tissue is limited, so it is not always a viable option. The aim of this work was to investigate tissue engineering as an alternative to autograft-based bone repair through the combination ...

Fracture healing is a complex regenerative process. Although the histology and general mechanism of repair process are already clear and well established, much remains to be understood about the process of bone healing. The source of the cells that initiate fracture repair are unclear. It is thoght that fracture repair is initiated by mesenchymal progenitor cells (MPCs) which undergo differenti...

PURPOSE The main purpose of the present clinical study was to compare architectural metric parameters using micro-computed tomography (μ-CT) between sites grafted with blocks harvested from the intramembranous origin calvarium and endochondral origin iliac crest for horizontal bone augmentation in the maxilla. The second aim was to compare primary stability of implants placed in both types of b...

Sutures, where neighboring craniofacial bones are separated by undifferentiated mesenchyme, are major growth sites during craniofacial development. Pathologic fusion of bones within sutures occurs in a wide variety of craniosynostosis conditions and can result in dysmorphic craniofacial growth and secondary neurologic deficits. Our knowledge of the genes involved in suture formation is poor. He...