1 Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, United Kingdom, 2 Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya, 3 Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 4 Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi,...

BACKGROUND Recurrent endobronchial infection in cystic fibrosis (CF) requires treatment with intravenous antibiotics for several weeks usually in hospital, affecting health costs and quality of life for patients and their families. OBJECTIVES To determine whether home intravenous antibiotic therapy in CF is as effective as inpatient intravenous antibiotic therapy and if it is preferred by ind...

Infections due to multidrug-resistant pathogens are increasing throughout the world, in particular due to the emergence of resistant Staphylococcus aureus, vancomycin-resistant enterococcus (VRE) penicillin-resistant Streptococcus pneumonia, multidrug-resistant (MDR) Pseudomonas and Acinetobacter spp, extended-spectrum β-lactamase(ESBL) producing enteric organisms, etc. These serious pathogens ...

Ventilator-associated pneumonia (VAP) continues to be a major complication of critical illness, and patient outcomes are often suboptimal. Approximately one third of patients receiving intravenous antibiotics alone will fail therapy. In addition, an increase in multidrug-resistant strains of Pseudomonas, Acinetobacter, and enterobacteriacae (eg, carbapenemase-producing Klebsiella) limits therap...

BACKGROUND Cecal diverticulitis is an uncommon cause of acute abdominal pain and presents clinically similar to acute appendicitis. There are many perspectives concerning the management of this condition, ranging from different types of surgical resections to conservative treatment with antibiotics. CASE REPORT We present 3 cases of cecal diverticulitis. One of the patients was treated conser...

Objectives The postoperative wound infection rate for canal wall reconstruction (CWR) tympanomastoidectomy with mastoid obliteration in the treatment of chronic otitis media with cholesteatoma has been reported to be 3.6%. Postoperative administration of 24-48 hours of intravenous antibiotics has been recommended. We aim to determine the infection rate of CWR with postoperative outpatient oral ...

Pulmonary exacerbations represent a key outcome variable in clinical trials of cystic fibrosis (CF). As there is variation in the trigger for use of intravenous antibiotics compared to the use of oral antibiotics or new nebulised therapy for treatment of exacerbations, the consensus view is that use of intravenous antibiotics cannot be regarded as the key defining character for an exacerbation ...