Problem statement: Some reports showed the teratogenic effects of sodium valproate can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Therefore, in this study, the prophylactic effect of melatonin on teratogenic effects of sodium valproate was compared. Approach: This study was performed on 31 pregnant rats that were divided into five groups. Con...

Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. Swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. These group...

A 19-year-old woman had secondary generalized seizures for 18 months due to a calcified parietal granuloma. She was treated with phenytoin (PHT) and sodium valproate. PHT was replaced with LEV 500 mg twice daily because of a recurrence of seizures. Having taken LEV for 10 days, she developed a generalized maculopapular itchy rash which spared the mucous membranes. LEV was stopped and she was pr...

A case of severe sodium valproate overdose is presented in which continuous venovenous haemodiafiltration was used. However, following the commencement of dialysis and a fall in the serum valproate levels, the patient developed cerebral oedema. This case demonstrated a poor correlation between serum valproate and its toxic effects and the lack of benefit of continuous venovenous haemodiafiltrat...

A double-blind crossover study of sodium valproate and placebo was conducted in five patients with Meige syndrome. CSF neurotransmitter studies were performed at the end of each treatment period. GABA levels were not influenced by the administration of sodium valproate. An increase in HVA levels was observed in every patient, which may reflect an increase in central dopaminergic activity. This ...

Epilepsy is one of the common neurologic disorders in children. Drug side-effects are one of the important problems in treating patients with epilepsy. Using the antiepileptic medication may cause different side effects such as disorder in bone and vitamin D metabolism. Sodium valproate is one of the antiepileptic medications used widely. Some of its side effects include digestive disorder, inc...

This study evaluated the protective effect of ellagic acid on sodium valproate-induced sperm abnormalities in male Wistar rats. A total of 30 rats were grouped into five groups, each having 6 animals. Vehicle, sodium valproate (400 mg/kg) and ellagic acid (10, 25, 50 mg/kg) were given orally from day 1 to day 7, and ellagic acid was continued for 3 more days. On day fourteen, animals were sacri...

sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. the aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. these group...