OBJECTIVE Serine protease 3 (PRSS3) is an isoform of trypsinogen, and plays an important role in the development of many malignancies. The objective of this study was to determine PRSS3 mRNA and protein expression levels in invasive ductal carcinoma of the breast and normal surrounding tissue samples. RESULTS Both PRSS3 mRNA and protein levels were significantly higher in invasive ductal carc...

Histological grading is a good parameter to stratify tumors according to their biological aggressiveness. The Elston and Ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. The aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. The samples included ...

OBJECTIVE To determine the frequency of the immunohistochemical profiles of a series of high-grade ductal carcinoma in situ of the breast. METHODS One hundred and twenty-one cases of high-grade ductal carcinoma in situ, pure or associated with invasive mammary carcinoma, were identified from 2003 to 2008 and examined with immunohistochemistry for estrogen receptor, human epidermal growth fact...

Skin-sparing mastectomy with immediate breast reconstruction can provide an excellent cosmetic result. Despite its increasing popularity, few studies have assessed the risk of recurrence when the procedure is used for the treatment of ductal carcinoma in situ. To evaluate the oncologic safety of skin-sparing mastectomy used for the treatment of ductal carcinoma in situ, the recurrence rate was ...

Mucinous carcinoma of the breast is a well differentiated, rare histological type of invasive ductal carcinoma, seen in oldest median age (69 years). We describe a case of a 60 yr old female with large right breast mass of 10 years duration with no nodal involvement. The reasons to present this case are 1) Because of its rarity. 2) Despite having a large tumour size, the axillary lymph node ...

PURPOSE Glucose uptake and glycolytic metabolism are enhanced in cancer cells, and increased expression of glucose transporter 1 (GLUT1) has also been reported. The aim of this study was to investigate GLUT1 expression in human breast tissues and invasive ductal carcinomas. METHODS We used tissue microarrays consisting of normal breast tissue, ductal hyperplasia, ductal carcinoma in situ, inv...

background : invasive ductal carcinoma is one of the most common type of tumors in females, constituting a single large group of breast cancers. there are various prognostic factors, of which tumor grade, size and axillary lymph node metastasis are among the important ones. fine needle aspiration cytology is a commonly used diagnostic technique in the initial evaluation of breast lumps. in the ...

histological grading is a good parameter to stratify tumors according to their biological aggressiveness. the elston and ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. the aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. the samples included ...