iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. in this study, the synthesis and determination of partition coefficients (kpart) of a range of n-alkyl hydroxypyridinones, as orally active iron chelators, are described. synthesis of n-aryl hydroxypyridinones was achieved via a single step synthetic pathway. in this method...

abstract background iron overload is the main transfusion related side effects in patients with transfusion dependent hemoglobinopathies. severe iron deposition in tissues leads to organ dysfunction. many organs can be affected such as heart, liver, and endocrine organs. cardiac failure and liver fibrosis are the consequent of iron overload in transfusion dependent hemoglobinopathy. magnetic re...

background: it is intriguing and imperative that the comparison of the iron preparations in hemodialysis (hd) patients. th is study aimed to observe the short-term effi cacy of parenteral iron sucrose and ferric chloride in hd patients. materials and methods: this was a consecutive 10-week single-blind study in taiwan. an intravenous iron supplement of 100 mg/week was administered as an infusio...

hydroxypyridinone iron chelators are currently the main candidates for development of orally active iron chelating alternatives to desferrioxamine (dfo). in the present study, the relative efficacy and liver toxicity of a bidentate chelator, 2-methyl-3-hydroxypyridin-4-one (mhpo), was studied in iron overloaded rats and compared with those of dfo. for iron overloading, rats received i.p. inject...

how to cite this article: ghasemi f, valizadeh f, taee n. iron-deficiency anemia in children with febrile seizure: a case-control study. iran j child neurol. 2014 spring 8(2):38-44. objective considering the recurrence of febrile seizure and costs for families, many studies have attempted to identify its risk factors. some recent studies have reported that anemia is more common in children with...