Within a fairly short amount of time, the Islamic State of Iraq and Syria (ISIS) has managed to put large swaths of land in Syria and Iraq under their control. To many observers, the sheer speed at which this “state” was established was dumbfounding. To better understand the roots of this organization and its supporters we present a study using data from Twitter. We start by collecting large am...

The Meta toolkit provides an infrastructure based upon the reac-tive system architecture for fault-tolerant management of distributed applications. Management policies are expressed as a set of rules, which are executed by Meta in a distributed fashion. The Meta system was implemented using ISIS as a basis. Although the concepts and architecture of Meta are independent of ISIS, the ISIS system ...

This document describes extensions to the ISIS (ISIS) protocol to support Multiprotocol Label Switching (MPLS) and Generalized MPLS (GMPLS) Traffic Engineering (TE) for multiple Autonomous Systems (ASes). It defines ISIS-TE extensions for the flooding of TE information about inter-AS links, which can be used to perform interAS TE path computation. No support for flooding information from within...

This paper presents an ISIS facilities ontology based on keywords in the ISIS Metadata catalog (ICAT) and OntoMaintainer, a web application to facilitate the collaborative development of ontologies. The ISIS facilities ontology aims to organize and make keywords in the ISIS Metadata Catalogue more explicit which will improve the search and navigation of data by category. The Ontology Maintainer...

Raf proteins play a central role in the mitogen-activated protein kinase signaling pathway and hence are involved in oncogenic transformation and tumor cell proliferation. ISIS 5132 is a 20-base antisense phosphorothioate oligodeoxyribonucleotide that specifically down-regulates c-raf expression. We report here an initial study of the safety and tolerability of an i.v. infusion of ISIS 5132 in ...

The pharmacokinetics of a 2'-O-(2-methoxyethyl)-ribose modified phosphorothioate oligonucleotide, ISIS 104838 (human tumor necrosis factor-alpha antisense), have been characterized in mouse, rat, dog, monkey, and human. Plasma pharmacokinetics after i.v. administration exhibited relatively rapid distribution from plasma to tissues with a distribution half-life estimated from approximately 15 to...

The first phase of ISIS has resulted in well established links between the participating companies and the research groups at LiTH (Linköpings Tekniska Högskola). The main activities within ISIS has been the research projects. These are chosen to be of central importance for the participating companies and many of the project results are of immediate industrial significance. The perhaps most di...