background: role of nitric oxide (no) in morphine-induced conditioned place preference (cpp) has already been proposed in the rat medial septum (ms), but no molecular evidence has been provided to clear this fact. methods: effects of intraseptal injections of l-arginine and/or ng-nitro-l-arginine methyl ester (l-name) on morphine place conditioning in wistar rats were examined. morphine (2.5-7....

Background: Role of nitric oxide (NO) in morphine-induced conditioned place preference (CPP) has already been proposed in the rat medial septum (MS), but no molecular evidence has been provided to clear this fact. Methods: Effects of intraseptal injections of L-arginine and/or NG-nitro-L-arginine methyl ester (L-NAME) on morphine place conditioning in Wistar rats were examined. Morphine (2.5-7....

increased arginase activity in the airways decreases l-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (no) in asthma. as, it is suggested that l-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled l-arginine on oxygen saturation (sao₂) and airway histology in a murine model of acute asthma. twenty eigh...

Background: The prevalence of hypertension in patients with type 2 diabetes (T2D) is approximately twice as much as healthy people. This study was designed to determine the effect of L-arginine supplementation on blood pressure in patients with T2D. Methods: In a double-blind randomized clinical trial, 75 T2D were randomly divided into three groups (3 g/d and 6g/d of L-arginine and placebo) for...

Background:epilepsy is one of the common neurological disorders and approximately 0.5-1% of populations suffers from it. Unfortunately, despite of treatment by antiepileptic drugs, between 20-30% of patients cannot be controlled completely. There are a lot of supplementary therapies for this group of patients and in this study, L-arginine was used as an additional therapy...

Introduction: The current study aimed at investigating the role of Nitric Oxide (NO) in the maintenance of anxiety and depression induced by stress in male Wistar rats using intra-Basolateral Amygdala (BLA) injection of NO precursor, L-arginine, Nitric Oxide Synthase (NOS) inhibitor, and L-NAME.  Methods: Two 23-gauge stainless steel cannulas were placed in the BLA, stereotaxically. Seven days...

  The involvement of nitric oxide (NO) in the reinforcing properties of opioids was studied by examining the effect of a NO precursor (L-arginine) and NO synthase inhibitor (L-nitro-amino-methyl-ester, L-NAME) on the conditioned place preference (CPP) induced by morphine. The experiment was performed on male albino Swiss- White mice (25 ± 5 g). L-arginine in doses of 100, 200 and 500 mg/kg (i.p...

background: the assessment of altered nitric oxide (no) availability is of potentially important diagnostic and prognostic significance. the present study is aimed to investigate the effect of l-arginine (as a natural no donor) supplementation on no metabolite in a rabbit model of hypercholesterolemia to find a reliable marker for endothelial no production. methods: white male rabbits (n = 30) ...

background: the refolding of proteins from inclusion bodies is affected by several factors, including solubilization of inclusion bodies by denaturants, removal of the denaturant, and assistance of refolding by small molecule additives. objectives: the purpose of this study was optimization of recombinant human interferon-b purification in order to achieve higher efficiency, yield, and a produc...