The effect of short- and long-term feeding with L-carnitine, L-acetyl carnitine and L-propionyl carnitine on the production of eicosanoids from in vitro stimulated carrageenan-induced rat peritoneal macrophages was investigated. Both young (4 weeks) and old (18 months) rats were used. A lower number of cells was isolated from the peritonea of treated than control young rats after 4 d feeding, b...

In this study, we sought to identify the transporters that mediate the uptake of L-carnitine and acetyl-L-carnitine in cultured rat cortical astrocytes. L-[(3)H]carnitine and acetyl-L-[(3)H]carnitine uptake were both saturable, and mediated by a single Na(+)-dependent transport system. Uptake of both was inhibited by L-carnitine, D-carnitine, acetyl-L-carnitine and various organic cations. Acyl...

This study aimed to evaluate the rumen protective effectiveness of L-carnitine through in vitro tests, degradation tests and vivo tests. Twelve rumen-fistulated crossbred rams with similar body weights 55±3.6 kg ages 3±0.2 years old were divided into three treatment groups a 3×3 Latin square design, G1 (basal diet no additives), G2 (unprotected L-carnitine) or G3 (rumen-protected L-carnitine). ...

cyclophosphamide (cp) is a mustard alkylating agent used in the treatment of a number of neoplastic diseases and as an immunosuppressant for the prevention of xenograft rejection. there are many reports that the teratogenic effects of cyclophosphamide can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. also, there is some evidence that l-carnitine...

conclusions acute l-carnitine supplementation possibly affects exercise performance and triglycerides in athletes rather than sedentary men. objectives this study aimed to investigate the acute effects of l-carnitine supplementation on aerobic metabolic efficiency and lipid profiles in sedentary and athletic men. methods fifteen sedentary (20.4 ± 1.5 years) and 15 athletic (21.5 ± 2.4 years) me...

this study was conducted to investigate the effects of l-carnitine and different levels of animal fat on performance, carcass characteristics and some blood parameters of broiler chickens. two hundred one-day old male broiler chicks were allotted to5 treatments in 4 replicates and 10 birds in each replicate. dietary treatments consisted of: 1) diet with 5% vegetable oil (t1), 2) diet with 5% ve...

Abstract Primary carnitine deficiency (PCD) can be lethal. Carnitine is essential for the transfer of long‐chain fatty acids across inner mitochondrial membrane β‐oxidation. The reported prevalence PCD in Faroe Islands 1:300 highest world. Faroese patient cohort has been closely monitored and we now report results from a 10‐year follow‐up study 139 patients. Four patients have died natural caus...