AIMS To investigate whether anomalies of transforming growth factor beta type II receptor (TGF-beta RII) expression occur in the early stages of laryngeal carcinogenesis and to assess their importance in the development of laryngeal squamous cell carcinoma. TGF-beta RII status was examined in laryngeal premalignant lesions coupled with malignant evolution and compared with a control group of si...

Aims—To investigate whether anomalies of transforming growth factor â type II receptor (TGF-â RII) expression occur in the early stages of laryngeal carcinogenesis and to assess their importance in the development of laryngeal squamous cell carcinoma. TGF-â RII status was examined in laryngeal premalignant lesions coupled with malignant evolution and compared with a control group of similar les...

INTRODUCTION HLA-G and HLA-E are two nonclassical class I molecules, which have been well recognized as modulators of innate and adaptive immune responses, and the expression of these molecules in virus infected cells has been associated with subversion of the immune response. OBJECTIVE In this study we performed a cross-sectional study, systematically comparing the expression of HLA-G and HL...

BACKGROUND P63 immunostaining has been considered as potential prognostic factor in laryngeal cancer. Considering that P63 is mainly nuclear stain, a possible correlation between the texture of P63-stained nuclei and the tumor's grade could be of value to diagnosis, since this may be related to biologic information imprinted as texture on P63 expressed nuclei. OBJECTIVE To investigate the ass...

Laryngeal histoplasmosis is a fungal infection that is frequent in Colombia. Laryngeal histoplasmosis usually occurs in immunocompromised patients through the dissemination of the fungus from the lungs to other organs. Histoplasmosis isolated laryngeal (primary) is rare. If a patient presents with a history of immunosuppression by renal transplant, primary laryngeal histoplasmosis with supraglo...

Vocal nodules and polyps are the most common benign laryngeal lesions. Recent studies have emphasized the importance of the clinicohistological correlation in laryngeal pathologies. The clinico-histological correlation of these lesions is not always easy, but an accurate diagnosis is of the utmost importance.

Background and purpose: Laryngeal cancers are associated with high rates of mortality and disability. No effective screening test is proven for this disease, so, the best way seems to be controlling the disease by identifying and eliminating individual predisposing factors. The aim of this study was to pave the way for a better understanding of the risk factors and factors affecting the type an...

Laryngeal squamous cell carcinomas (LSCC) are the most frequently seen cancers among head and neck squamous cell carcinomas (HNSCC), and they constitute 1-2% of all malignancies worldwide (Sadri et al., 2006). Laryngeal carcinogenesis is a multifactorial process that has not been fully elucidated. LSCC develops as a result of structural and cytological alterations in the laryngeal squamous epit...

Lesions to the laryngeal nerves, despite their low incidence, are the most severe long term complications after thyroidectomy.Visualization after careful dissection of the recurrent laryngeal nerve (RLN) is now the gold standard among thyroid surgeons. The Zuckerkandl tubercle (TZ) is a constant landmark for the identification of the RLN. Recent studies show the occurrence of two or more branch...

Objective. To compare the surgeon's evaluation and histopathology for diagnosis of laryngeal lesions. Material. A clinical survey was distributed to laryngeal surgeons, ENT clinicians, and students in 2013 at the Department of Otorhinolaryngology in Rostock. Participants were asked to anonymously identify laryngeal pathologies and to assess the severity of the lesion starting from hyperplasia a...