Therapeutic preparations of botulinum toxin products are calibrated by a mouse LD50 assay, and the labelled unit of activity is expressed in mouse LD50 units, defined as the median lethal intraperitoneal dose at a defined time-point. Potency and stability testing are required at several stages of the production process. Testing at the final lot stage requires high precision, so a large number o...

adonis aestivalis (summer pheasant-eye) is an annual plant with a crimson flower, distributed in southern europe and asia. the plant has large buttercup-like blossoms and soft, fern-like leaves. it blooms in spring and is often found as a weed in cereal fields. like other adonis spp., the plant produces cardiac glycosides. it is used in remedies for mild weakness of the heart, especially when a...

Concepts of QSAR analysis and biological similarity models are combined for use in extrapolation of LD50 values after IP application of a series of aliphatic alcohols (C1-C5) to mouse, hamster, rat, and guinea pig and rabbit. It has been found that although close correlation exists between LD50 values after IP and IV applications for mouse and rat, the QSARs obtained with LD50 after IV applicat...

The application of the following new indices of the efficacy of antidotes has been substantiated and discussed: the "antidotal potency" as a ratio of LD50 of a poison when an antidote used to LD99 in control intact animals, and the "index of solid protection" as a ratio of LD10 in the experiments to LD90 in controls. The two indices are true for changing the lethality curve slope, which makes i...

The aim of this research was to evaluate acute toxicity of the essential oil of leaves of Chinese chives, Allium tuberosum Rottler ex Spreng (Asparagales: Alliaceae) and its major constituents against Apolygus lucorum Meyer-Dür (Hemiptera: Miridae). The essential oil of A. tuberosum leaves was obtained by hydrodistillation and analyzed by gas chromatography and gas chromatography-mass spectrome...

1. The effect of methamphetamine on morphine-dependent mice was investigated by calculating the LD50 (i.p.), measuring motor activity, anorectic actions, and body temperature. 2. Methamphetamine was more toxic in morphine-dependent mice (LD50 = 20.6 mg/kg) than in normal mice (LD50 = 43.2 mg/kg). 3. Methamphetamine-induced locomotor activity was greater in morphinized than in nonmorphinized mic...

Özet: Bu çalışmada, Kayseri bölgesinde tarım alanlarında kullanılan insektisitlerden biri olan diazinonun testis dokusuna olan etkilerinin histokimyasal olarak araştırılması amaçlanmıştır. Araştırmada kullanılan sıçanlar 5 gruba ayrıldı. Birinci deney grubuna 1 gün LD50 dozunun (1250 mg/kg) 1/10’u, ikinci deney grubuna 2 gün LD50 dozunun 1/20’si, üçüncü deney grubuna 4 gün LD50 dozunun 1/40’ı, ...