The effects of intravenous lignocaine and atropine in preventing cardiac arrhythmias were evaluated in forty-five psychiatric patients undergoing electroconvulsive therapy. During the electrical shock a more prolonged asystole was observed in the lignocaine than in the atropine group. During the tonic-donic seizure ventricular extrasystoles appeared in six atropinized patients. During the postc...

In four groups of six rats a random dorsal flap was raised, and 5, 20, or 200 mg/ml lignocaine or 0.9% sodium chloride, were injected intradermally. Cutaneous laser Doppler blood cell flux was measured at 12 time points over 130 minutes. In six other groups 5, 20, 100, 200, or 400 mg/ml lignocaine concentrations, or sodium chloride were tested. Blood cell flux was measured at the time that the ...

We have evaluated the effects of lumbar extradural morphine and lignocaine on the ventilatory response to carbon dioxide. Twenty-four female patients were allocated randomly to receive extradural morphine 2 mg (group M), 2% lignocaine 10 ml (group L) or a combination of morphine 2 mg and 2% lignocaine 10 ml (group ML). On the day before surgery, resting ventilatory values including minute volum...

OBJECTIVE To compare tourniquet tolerance and postoperative analgesia using lignocaine intravenous regional analgesia alone or with addition of dexamethasone and ketorolac. METHODS The randomised, prospective study was conducted at Mayo Hospital, Lahore, from June 2013 to June 2014. Patients were divided into three groups: group I received lignocaine; group II received lignocaine and 30mg ket...

Background: Purpose of the study was to evaluate the efficacy of Atracurium as adjuvant with tramadol or Ketorolac in reducing the dose of lignocaine used for intravenous regional anesthesia thereby decreasing the chances of systemic toxicity of lignocaine. Patients and Methods: The study was done in Department of Anaesthesia, Santhiram Medical College and General Hospital, Nandyal. 75 adult pa...

INTRODUCTION Despite the availability of a wide variety of pharmacological agents in the field of anesthesia, there has always been a continuous search for newer local anesthetic agents with improved efficacy, potency, and better handling properties. Dexmedetomidine, a selective alpha-2 adrenergic receptor agonist, is an emerging agent for provision of additive local anesthetic effect if used w...

BACKGROUND To investigate the effects of intravenous lignocaine infusions (IV lignocaine) in fibromyalgia. METHODS Prospective study of the adverse effects of IV lignocaine in 106 patients with fibromyalgia; retrospective questionnaire study of the efficacy of IV lignocaine in 50 patients with fibromyalgia. RESULTS Prospective study: Two major (pulmonary oedema and supraventricular tachycar...

The effects were studied, in eight healthy volunteers, of premedication with diazepam 0.14 mg kg-1 by mouth or hyoscine 6 micrograms kg-1 + morphine 0.2 mg kg-1 i.m., or no premedication, on toxic symptoms and plasma concentrations after rapid i.v. injection of lignocaine 1 mg kg-1. The alpha 1-acid glycoprotein (AAG) and albumin plasma protein fractions were assessed. A variety of mild central...

A comparison of the antiarrhythmic effects of 2 mg/kg of mepivacaine and lignocaine, as measured by elevations in the end-diastolic ventricular stimulation threshold (EDVST), was made in open-chest dogs. Both mepivacaine and lignocaine increased the EDVST significantly. The peak elevation of EDVST occurred within 2 minutes after injection and averaged 0.013 mA (13 ,uA) with mepivacaine and 0.02...

Plasma concentrations of lignocaine were measured during and after infusion of lignocaine at 1.4 mg/min for 36-46 hours in 12 patients with myocardial infarction and one patient with cardiac failure due to uncontrolled ventricular tachycardia. In six patients without cardiac failure the plasma concentrations of lignocaine rose progressively during the infusion and the mean lignocaine half life ...