There are reports of an association between megaloblastic anaemia and rheumatoid arthritis. Partridge and Duthie (1963) found megaloblastic anaemia in 1 38 per cent. (35 cases) of 2,544 rheumatoid arthritis patients, as opposed to 0-27 per cent. (15 cases) of 5,515 controls. Of the 35 rheumatoid patients with megaloblastic anaemia, 27 were thought to have Addisonian pernicious anaemia, an incid...

By FARm 1. FIAuRANI, GEORGE WANG AND L. M. T0cANrINs I HE COMMON types of megaloblastic anemias usually res1)ond well to vitamin B-12 or folic acid but there are some which respond incompletely or not at all to these antianemic agents. In 1936, Israel and \Vilkinson referred to these megaloblastic anemias which are refractory to liver extract as “Achrestic n1 ‘ Since then a number of cases have...

Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic erythropoiesis. Of the many causes of megaloblastic anemia, the most common are disorders resulting from cobalamin or folate deficiency. The clinical symptoms are weakness, fatigue, shortness of breath and neurologic abnorma...

The absorption of (60)CoB(12) has been studied in a group of patients suffering from megaloblastic anaemia associated with pregnancy and in a control group. The mean urinary excretion of (60)CoB(12) in the patients with megaloblastic anaemia is not significantly different from that of the control group. Five of the 30 patients showed a value towards the lower limit of normal, but the serum vita...

The common anaemia in premature infants is iron deficiency anaemia, but megaloblastic anaemia can also occur and here we report three such cases. Our interest in megaloblastic anaemia was stimulated by a recent case in which megaloblastic anaemia developed when a low phenylalanine diet was being given for treatment of phenylketonuria (Royston and Parry, 1962). In the discussion of this paper Ro...

Psoriasis is known to be one of the skin diseases which can cause folate deficiency (1-3). However, psoriasis alone rarely produces folate deficiency severe enough to be associated with megaloblastic anemia (1-3). Recently, methotrexate has been widely used as an effective therapy for patients with severe psoriasis who are resistant to conventional agents (4), but such therapy increases the ris...

repeated bone marrow examination was found to be of value in assessing response to treatment in megaloblastic anemia. the objective of this study was monitoring the response of megaloblastics to treatment, concerning the location of neutrophilic myeloperoxidase and myeloperoxidase index (mpxi) and their variation in megaloblastic erythroid progeny. it is possible to follow up megaloblastic case...

Direct destruction and ineffective erythropoesis does not adequately explain the cause of anaemia in malaria. It is possible that there are more other mechanisms involved besides the causes described till date in malarial anaemia. The effect of NO on erythropoesis and a major haematological abnormality (microcytic/normocytic/megaloblastic picture) can significantly be observed on repeated expos...