PURPOSE Chemotherapy-induced cognitive impairment (CICI) is a common sequelae of cancer therapy. Recent preclinical observations have suggested that CICI can be mediated by chemotherapy-induced plasma protein oxidation, which triggers TNF-α mediated CNS damage. This study evaluated sodium-2-mercaptoethane sulfonate (Mesna) co-administration with doxorubicin to reduce doxorubicin-induced plasma ...

INTRODUCTION It is important for sarcoma patients to receive the correct dose of Mesna as an adjuvant with ifosfamide to reduce the risk of hemorrhagic cystitis. This paper describes a study conducted to evaluate the physicochemical stability of Mesna for injection formulation over 14 days. METHODS Mesna samples (n = 4, 20 mg/ml) were incubated in glass vials at 37 + 0.5ºC. Mesna concentratio...

The nephrotoxic activity of cis-diammine-dichloroplatinum (CDDP), an important cytostatic agent in modern cancer chemotherapy, has most commonly limited the effective use of this drug (Rozencweig et al., 1977; Gonzalez-Vitale et al., 1977; Campbell et al., 1983; Offerman et al., 1984). As in man, typical pathological changes in the kidneys after CDDP application can also be found in laboratory ...

Objective(s) There are some reports that the teratogenic effects of cyclophosphamide (CPA) can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Echinacea purpurea extract is antioxidative and immunomodulator drug. Mesna (Sodium 2-mercaptoethane sulfonate) is used for decreasing side effects of CPA, especially hemorrhagic cystitis. In this study, w...

PURPOSE We conducted our study to determine the pharmacokinetics (PK) and clinical efficacy of oral mesna in patients receiving ifosfamide for soft tissue sarcoma. EXPERIMENTAL DESIGN Seventeen patients were enrolled in a randomized prospective Phase I/II study. Seventeen patients were exposed to study medication. Ifosfamide was given at a dose of 2 g/m2/day for 5 days on a 21-day cycle. Befo...

Lung fibrosis is a common side effect of the chemotherapeutic agent, bleomycin. Current evidence suggests that reactive oxygen species may play a key role in the development of lung fibrosis. The present study examined the effect of mesna on bleomycin-induced lung fibrosis in rats. Animals were divided into three groups: (1) saline control group; (2) Bleomycin group in which rats were injected ...

Increasing the urinary output of free thiol groups protects against cyclophosphamide-induced bladder toxicity. In the present study, intact rats, isolated perfused kidneys, and freshly isolated cells from various rat organs are used to compare the efficacy of N-acetylcysteine and sodium 2-mercaptoethane sulfonate (mesna) as sources of urinary thiols. In intact rats given a single i.v. dose of m...

objective(s) there are some reports that the teratogenic effects of cyclophosphamide (cpa) can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. echinacea purpurea extract is antioxidative and immunomodulator drug. mesna (sodium 2-mercaptoethane sulfonate) is used for decreasing side effects of cpa, especially hemorrhagic cystitis. in this study, we...

BACKGROUND The nephrotoxicity induced by contrast media remains a serious clinical problem, and the underlying mechanism has not been completely understood. Experimental and clinical investigations suggest that reactive oxygen species (ROS) are critical determinants of radiocontrast nephropathy (RCN), and that antioxidants can prevent this damage. METHODS Cultured human proximal renal tubule ...

Implant-associated surgical-site infections can have significant clinical consequences. Previously we reported a method for prophylactically disinfecting implant surfaces in surgical pockets, where an antibiotic solution containing minocycline (M) and rifampin (R) was applied as a solid film in a crosslinked biopolymer matrix that partially liquefied in situ to provide extended prophylaxis. Her...