Background: Melanoma causes the greatest morbidity and mortality of all skin cancers. Mucosal melanoma is a rare but highly aggressive neoplasm. According to previous studies the prevalence of KIT mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. Our goal w...

Background: A soluble form of HER-2/neu extracellular domain (sHER-2) is reported to be released in the sera of metastatic breast cancer patients. Objective: To measure the level of sHER-2 in sera of 115 breast cancer patients. Methods: Serial samples of 27 patients with metastasis, 18 non-metastatic patients, 15 patients in stage 0/I and 14 patients with accompanying benign breast disease were...

statement of the problem: the head and neck region is an uncommon site for metastatic involvement, but it can be the first and only symptom of primary cancer. the incidence of these tumors and their primary origins are limited in iranian patients. purpose: therefore, this retrospective study aimed to investigate the frequency and the common related clinical manifestations, as well as, the most ...

early recognition of gestational trophoblastic neoplasm (gtn) will maximize the chances of cure with chemotherapy but some patients present with many different symptoms months or even years after the causative pregnancy making diagnosis difficult. clinicians should be aware of the possibility of gtn in any reproductive age woman with bizarre central nervous system, gastrointestinal, pulmonary s...

In this study, 22 patients (15-75 years old) were selected and transferred to CT scan for tumor ablation. For ablations, after prep and drep under the local anesthesia and mild sedation in proper position, small incision made and special needle inserted and guided by proper direction to the core of the tumor. Then, laser probe inserted through the needle and laser energy delivered. Although we ...

Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological pathological conditions. They contain signature tumor-derived molecules that reflect intracellular status their cell origin. Recent studies have shown tumor cell-derived EVs can aid cancer metastasis through modula...

A patient diagnosed with advanced lung cancer developed severe dyspnea after chemotherapy. Metastatic tumor completely obstructing the lower trachea was revealed by bronchoscopy. Emergent surgery required but it difficult to perform open tracheal and maintain sufficient ventilation intubation because of location size tumor. After consultation an esthesiologist, respiratory physician cardiothora...

Previous NGS experiments showed that distinct parts of the same tumor different mutation profiles. Additionally, primary tumors and their metastases can differ in mutational pattern. In this study, we compare KRAS status between colorectal cancer tissue recurrent/metastatic sites. Four patients with metastatic adenocarcinoma were screened for mutations by Idylla automated testing on two tissues...

pancreatic neuroendocrine tumors (pnet) are uncommon pancreatic neoplasms, accounting for 1-2% of all pancreatic tumors. however, they have a better prognosis and long-term survival compared to exocrine pancreatic cancer. pnets can be divided into functional or non-functional based upon whether or not they excrete active substances relevant to specific clinical syndromes. skeletal muscle metast...