Anteroposterior polarity in early C. elegans embryos is required for the specification of somatic and germline lineages, and is initiated by a sperm-induced reorganization of the cortical cytoskeleton and PAR polarity proteins. Through mechanisms that are not understood, the kinases PAR-1 and PAR-4, and other PAR proteins cause the cytoplasmic zinc finger protein MEX-5 to accumulate asymmetrica...

Protein concentration gradients encode spatial information across cells and tissues and often depend on spatially localized protein synthesis. Here, we report that a different mechanism underlies the MEX-5 gradient. MEX-5 is an RNA-binding protein that becomes distributed in a cytoplasmic gradient along the anterior-to-posterior axis of the one-cell C. elegans embryo. We demonstrate that the ME...

An Einstein’s connection which takes the form (3.1) is called an ME-connection. A generalized n-dimensional Riemannian manifold X, on which the differential geometric structure is imposed by a tensor field *gx through a unique ME-connection subject to the conditions of Agreement (4.1) is called "g-ME-manifold and we denote it by "g-MEX.. The purpose of the present paper is to introduce this new...

Mexiletine (Mex) has been recently appointed as an orphan-drug in myotonic-syndromes, being a potent use-dependent blocker of skeletal-muscle sodium channels (NaV1.4). Available evidences about a potential anti-oxidant effect of Mex and its tetramethyl-pyrroline-derivatives in vivo, suggest the possibility to further enlarge the therapeutic potential of Mex-like compounds in myopathies in which...

AIM Mexico implemented annual tax increases between 2009 and 2011. We examined among current smokers the association of price paid per cigarette and daily cigarette expenditure with smoking-induced deprivation (SID) and whether the association of price or expenditure with SID varies by income. METHODS We used data (n=2410) from three waves of the International Tobacco Control Mexico survey (i...

Polarization of the C. elegans zygote along the anterior-posterior axis depends on cortically enriched (PAR) and cytoplasmic (MEX-5/6) proteins, which function together to localize determinants (e.g. PIE-1) in response to a polarizing cue associated with the sperm asters. Using time-lapse microscopy and GFP fusions, we have analyzed the localization dynamics of PAR-2, PAR-6, MEX-5, MEX-6 and PI...

Gebhardt et al. (2014) presented the Monitoring Activity Data for the Mexican REDD+ program (MAD-MEX), an automatic nation-wide land cover monitoring system for the Mexican REDD+ MRV. Though MAD-MEX represents a valuable first effort toward establishing a national reference emissions level for the implementation of REDD+ in Mexico, in this paper, we argue that this land cover system has importa...

OBJECTIVES We investigated whether the Na+-H+ exchange inhibitor, HOE642 (Hoe), and/or the Na channel blocker, mexiletine (Mex), enhance a cardioprotective effect on St. Thomas' Hospital cardioplegic solution (STS) to clarify the mechanism by which intracellular Na+ is accumulated after cardioplegic arrest. MATERIALS AND METHODS Isolated working rat hearts were perfused with Krebs-Henseleit b...

Oxidative stress has been implicated as an important factor in the process of neurodegeneration and hydrogen peroxide (H₂O₂) is one of the most important precursors of reactive oxygen species (ROS), responsible for many neurodegenerative diseases. This study used extracts from Nardostachys jatamansi rhizomes, known for nerve relaxing properties in Ayurvedic medicine, to ascertain their protecti...

The specification of all aspects of a programming language requires adequate formal models and tool support. Montages specifications combine graphical and textual elements to yield language descriptions similar in structure, length, and complexity to those in common language manuals, but with a formal semantics. A broad range of people involved in programming language design and use may find it...