Introduction:  Asthma exacerbation is common in children. Treatment with oral corticosteroids (OCS) and inhaled corticosteroids are suggested for asthma exacerbation. It is shown that inhaled corticosteroids has similar outcome in reducing asthma symptoms compared to OCS. But few studies have evaluated the pulmonary function changes in these two treatments. In this study, we evaluated the chang...

Background Asthma is a chronic inflammatory disease in respiratory system and obesity is another inflammatory disease which incidence rate is increasing. Although, many studies have been conducted on severity of asthma and its relationship with obesity, but different results have been obtained. This study aimed to determine a relationship between asthma severity, Body Mass Index (BMI) and pulmo...

Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...

the results of many studies suggested possible relationship between polymorphism at codons 16 and 27 and development of tolerance to beta-2 adrenoceptor agonist responses as well as disease severity in asthmatic patients. this study was designed to evaluate the effect of polymorphism of beta2 adrenoceptors on response to salmeterol and fluticasone (as inhaled seretide). sixty-four patients with...

Abstract Due to the increased number of patients suffering from asthma, mechanism this disease has been subject much attention public and finding a cure for is urgent. A changed abundance microbiome proven play an important role in genesis development asthma. In study, function were studied. It was found that there significant changes components when asthma mild severe. This study could help us...

Background: Conflicting results from previous studies on the effect of bronchial challenge on ven¬ tilatory patterns in asthmatics may be due to airflow obstruction present before induction of bron¬ chospasm onset, as well as the different degrees of bronchoconstriction induced. Purpose and methods: We examined the ventilatory response to stepwise increments in respiratory resistance (Rrs) indu...

Background: Asthma is one of the most common persistent inflammatory respiratory disorders. Comorbidities are relatively common in asthma. The aim of this review study was to find comorbid disorders in children with asthma. Methods: For the purpose of this review, we searched databases including Scopus, Google scholar, PubMed, SID, Irandoc and up-to-date. Key words for the search included chil...

Objective: Asthma consensus guidelines recommend the use of a controller agent to control asthma symptoms and reduce inflammation in patients with mild asthma. The objective of this study was to compare montelukast to inhaled fluticasone on the percentage of asthma-free days in patients with mild persistent asthma during 48 weeks of active treatment. Methods: This was a randomized, multicenter ...