The aim of the work was to examine the influence of gender on pharmacokinetics of silymarin; a basic constituent of medicinal herb "milk thistle" (Silybum marianum). The presented work is the extension of published work of Usman et al. (16). The comparative parallel design pharmacokinetic study was conducted in Pakistani healthy volunteers (male and female) receiving a single 200 mg oral dose o...

Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver complications, depression, dyspepsia, spleenic congestions, varicose veins, diabetes, amenorrhea, uterine h...

the pollutants due to effect on the immune system of fish increase fish sensitivity to pathogens. diazinon is one of the most used organophosphates pesticide in many agricultural areas. this study aimed to evaluate the effect of diazinon on the immune system of rainbow trout ( oncorhynchus mykiss ) and application of milk thistle plant, vitis vinifera extract to reduce the adverse effects of th...

Women at high risk of developing breast cancer are prescribed selective estrogen response modulators, including raloxifene, as chemoprevention. Patients often seek complementary and alternative treatment modalities, including herbal products, to supplement prescribed medications. Milk thistle preparations, including silibinin and silymarin, are top-selling herbal products that may be consumed b...

H. Fallah Huseini*, B. Larijani, R. Heshmat, H. Fakhrzadeh, B. Radjabipour, T. Toliat and Mohsin Raza Department of Pharmacology, Institute of Medicinal Plants, ACECR Tehran, Iran Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Physiology, School of Medical Sci...

Background & Aim: Milk thistle [Silybum marianum (L.) Gaertn] is an annual or biennial plant, native to the Mediterranean area, which has spread in north and south of Iran. A fruit of milk thistle contains a relatively high amount (approx. 20%) of oil, which exhibits wound-healing, anti-burn, and hepatoprotective properties. Experimental: In this research, a pot experiment wa...

Silybum marianum is the scientific name of milk thistle. For centuries, it used to treat hepatitis, cirrhosis, jaundice, diabetes, and indigestion. The bioactive agents thistle contain Apigenin, silybin, betaine, free fatty acids, silychristin, silidianin. Objective: To determine potential (milk thistle) in non-alcoholic liver disease patients. Methods: It was a cross-sectional experimental bas...

The gram-scale isolation of the major flavonolignan diastereoisomers from milk thistle ( Silybum marianum) extract provided an entree into the isolation of two related analogues that are present in extremely minute quantities. The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin ...

Recent studies have shown an increase in alcohol-related digestive and liver diseases as alcohol consumption grew during the COVID-19 pandemic. Patients may embrace milk thistle—which has been promoted a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion—to protect from environmental toxins. With hundreds of years history treatment wide range disorders gallbladder prob...