BACKGROUND The purpose of this study was to identify miRNAs and genes involved in nasopharyngeal carcinoma (NPC) radioresistance, and explore the underlying mechanisms in the development of radioresistance. METHODS We used microarrays to compare the differences of both miRNA and mRNA expression profiles in the radioresistant NPC CNE2-IR and radiosensitive NPC CNE2 cells, applied qRT-PCR to co...

MicroRNAs (miRNAs) regulate gene expression posttranscriptionally. Although previous efforts have demonstrated the functional importance of target sites on miRNAs, little is known about the influence of the rest of 3' untranslated regions (3'UTRs) of target genes on microRNA function. We conducted a genome-wide study and found that the entire 3'UTR sequences could also play important roles on m...

Using a homology search based on genomic survey sequence analysis and microRNA (miRNA) secondary structure, a total of 51 miRNA genes encoding 30 amphioxus miRNAs were identified. These amphioxus miRNAs belong to 27 miRNA families. Many miRNA genes were found in multiple locations and in more than one genomic context. Analysis of amphioxus miRNA genes revealed nearly 50% miRNA genes identified ...

MicroRNAs (miRNAs) are a class of non-coding RNAs that hybridize to mRNAs and induce either translation repression or mRNA cleavage. Recently, it has been reported that miRNAs could possibly play an important role in human diseases. By integrating miRNA target genes, cancer genes, miRNA and mRNA expression profiles information, a database is developed to link miRNAs to cancer target genes. The ...

Published genome sequences can facilitate multiple sequencing studies of flower development, which serve as the basis for later analysis variation in phenotypes. To identify potential regulators related to morphology, we captured dynamic expression patterns under five different developmental stages petunia flowers, a popular bedding plant, using transcriptome and miRNA sequencing. The significa...

objective(s): the purpose of this study was to conduct a meta-analysis on human micrornas (mirnas) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. materials andmethods: pubmed, embase, web of science, ovid medline were used to search for endometriosis mirna expression profiling studies of endometriosis. the mirn...

We computationally reanalysed public domain data set deposited to gene expression omnibus, of mRNA expression, miRNA expression and promoter methylation pattern in four brain regions, i.e., frontal cortex, temporal cortex, pons and cerebellum. Then we found that more than hundreds of both miRNA regulation of target genes and miRNA-targeting-specific promoter methylation are significant on all s...