COVID-19 severe symptoms and high mortality are mainly seen in elders with age-associated diseases who have mitochondrial dysfunction. Mitochondrial dysfunction is a vulnerability comorbidity of COVID-19. Cytokine storm, increased serum iron ferritin reactive oxygen species (ROS) further damage mitochondria. Amelioration may be strategy prevention treatment We also describe organelle transplant...

Coenzyme Q (CoQ) is a key component for many essential metabolic and antioxidant activities in cells mitochondria cell membranes. Mitochondrial dysfunction one of the hallmarks aging age-related diseases. Deprivation CoQ during can be cause or consequence this mitochondrial dysfunction. In any case, it seems clear that aging-associated deprivation accelerates these Non-genetic prolongevity inte...

Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD. In recent years, mitochondrial dysfunction has been strongly associated with tau pathology in AD. Overexpression of hyperphosphorylated and aggregated tau appears to damage the ...

Multiple Sclerosis (MS) is a neurodegenerative and autoimmune disease that it’s molecular etiology and factors involving in its progression remains unknown. In this study for evaluation effect of mercuric on progression of MS we investigated the additive effect of mercuric sulfide on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (EAE) model of MS in C57BL/6 mi...

Mitochondrial dysfunction is a key driver of neurodegeneration. This study aimed to evaluate the protective potential EPOR/CD131 (heterodimeric erythropoietin receptor) stimulation in neurodegeneration caused by rotenone-induced mitochondrial dysfunction. The effects (EPO) and an EPO mimetic peptide pHBSP were assessed using vivo vitro models. Single injections 10 µg/kg or 5 significantly allev...

multiple sclerosis (ms) is a neurodegenerative and autoimmune disease that it’s molecular etiology and factors involving in its progression remains unknown. in this study for evaluation effect of mercuric on progression of ms we investigated the additive effect of mercuric sulfide on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (eae) model of ms in c57bl/6 mi...