Background: L1 retrotransposons are the most active mobile DNA elements in human genome. Unregulated L1 retrotransposition may have deleterious effect by disrupting vital genes and inducing genomic instabilities. Therefore, human cells control L1 elements by silencing their activities through epigenetic mechanisms. It has been shown that cell division and heavy metals stimulate the frequency of...

purpose : to evaluate the efficacy and safety of subconjunctival oculusgen implantation when used during trabeculectomy methods : in this prospective, nonrandomized, interventional case series, 10 eyes of 10 patients with medically uncontrolled open angle glaucoma were enrolled. conventional fornix based trabeculectomy with implantation of subconjunctival biodegradable collagen implant (oculusg...

purpose: to assess the efficacy of intraoperative mitomycin c (mmc) during silicone intubation (si) as a substitute for dacryocystorhinostomy (dcr) in nasolacrimal duct (nld) obstruction. methods: in a prospective, randomized, double-blind study, 88 candidates of dcr for nld obstruction were randomly assigned into two groups of si with application of either mmc (0.2 mg/ml for 2 minutes) or plac...

The dimethyl sulfoxide induced erythropoietic differentiation of murine erythroleukemia cells, as determined by scoring benzidine positive cells, is inhibited by mitomycin C at concentrations that have no effect on cell proliferation. The inhibition occurs only when cells are treated with mitomycin C during induction and has a limit value of about 50%, independent of mitomycin C concentration. ...

The dimethyl sulfoxide induced erythropoietic differentiation of murine erythroleukemia cells, as determined by scoring benzidine positive cells, is inhibited by mitomycin C at concentrations that have no effect on cell proliferation. The inhibition occurs only when cells are treated with mitomycin C during induction and has a limit value of about 50%, independent of mitomycin C concentration. ...

OBJECTIVE Topical application of mitomycin C appears to be a useful adjunct in reducing cicatricial scarring of the airways. Human and animal studies have demonstrated the efficacy and safety of mitomycin C topically in the treatment of airway stenosis at concentrations ranging from 0.4 mg/mL to 10 mg/mL. Although no reports of mitomycin C toxicity have been reported in the otolaryngology liter...

BACKGROUND The clinical effect of intravesical instillation of chemotherapy immediately after transurethral resection of bladder tumours (TURBT) has recently been questioned, despite its recommendation in guidelines. Our aim was to compare TURBT alone with immediate post-TURBT intravesical passive diffusion (PD) of mitomycin and immediate pre-TURBT intravesical electromotive drug administration...

PURPOSE Electrochemotherapy is widely performed to treat solid tumors but experience with bladder cancer is limited. We investigated mitomycin C and cisplatin administered with electrochemotherapy for bladder cancer in vitro and in vivo. MATERIALS AND METHODS The human bladder cancer cell line SW780 was used. Cells were treated with electroporation, drug alone or electroporation plus increasi...

PURPOSE To determine if a pterygium surgical procedure consisting of minimal conjunctival removal, excision of the hypertrophic subconjunctival fibrovascular tissue, application of mitomycin 0.25 mg/mL for 1 minute combined with temporary nasal tarsorrhaphy, and use of postoperative dexamethasone/antibiotic drops achieves the following: safely simplifies pterygium removal, controls the early si...

introduction: this study was performed to determine the efficacy of mitomycin c on synechia after fess in ethmoid sinuses in patients admitted in imam-khomeini hospital in 2011 and 2012. methods: in this interventional study, 30 patients with pan rhinosinusitis attending to imam-khomeini hospital in 2011 and 2012 were enrolled and in one side after fess, the mitomycin c and in the other side th...