Background: L1 retrotransposons are the most active mobile DNA elements in human genome. Unregulated L1 retrotransposition may have deleterious effect by disrupting vital genes and inducing genomic instabilities. Therefore, human cells control L1 elements by silencing their activities through epigenetic mechanisms. It has been shown that cell division and heavy metals stimulate the frequency of...

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PURPOSE The authors performed a prospective evaluation of the efficacy of treating ocular cicatricial pemphigoid (OCP) with subconjunctival mitomycin C. DESIGN Unmasked, prospective, internally controlled case series. METHODS Patients were eligible for treatment with subconjunctival mitomycin C under three criteria: (1) significant complications of systemic immunosuppressant therapy; (2) ma...

purpose : although applying mitomycin c (mmc) during photorefractive keratectomy (prk) has shown to reduce postoperative corneal haze but there is considerable evidence of mmc toxicity in the literature and concerns exist regarding side effects and long-term complications. we conducted this study to compare the efficacy of mmc 0.02% and 0.01% in prevention of haze after prk. methods : 210 eyes ...

Numerous studies have shown that topical application of mitomycin C after surgical decompression effectively reduces scar adhesion. However, the underlying mechanisms remain unclear. In this study, we investigated the effect of mitomycin C on the proliferation and apoptosis of human epidural scar fibroblasts. Human epidural scar fibroblasts were treated with various concentrations of mitomycin ...

Introduction: Corrosive ingestion is the major cause of esophageal stricture in our country. Mitomycin–C, an anthracycline derived from Streptomyces caespitosus, has both antineoplastic and antiproliferative properties. Use of mitomycin–C have been well documented in various ophthalmologic procedures and laryngo-tracheal conditions where it has been shown that mitomycin–C inhibited fibroblast p...

background: using bouginage or balloon dilatation is the standard treatment for benign esophageal strictures. aùžbout two-thirds need repeated dilatations. for preventing recurrent strictures, many medications such as mitomycin-c have been used. mitomycin-c is a special antibiotic with anti-neoplastic characteristics, which inhibits fibroblast proliferation, reduces collagen production and decr...