OBJECTIVE Accumulating evidences suggest that cancer-associated fibroblasts are provided from bone-marrow-derived mesenchymal stem cells (BM-MSCs); however, little is known about the mechanism(s) by which BM-MSCs accelerate cancer aggressiveness. METHODS Gastric carcinoma (GC)-derived MKN-7 cells were cocultured with UE6E7T-12 BM-MSCs. The gene expression profile in MKN-7 cells was investigat...

We discuss an effect of the intergalactic absorption of the TeV γ-rays in time-averaged spectrum of Mkn 501 measured by the HEGRA collaboration. Analysis of the spectral behavior, variability time scale and relevant calculations of TeV γ-ray emission allow to conclude the presence of a noticeable absorption of the TeV γ-rays in the Mkn 501 energy spectrum.

BACKGROUND FBG2 (F-BOX6) gene is an important member in ubiquitin metabolic system F-BOX family, and forms E3 complex with the other members in the family. But its role in gastric cancer is still not clear. In the present study, we intended to investigate the influence of FBG2 on the growth, proliferation, apoptosis, invasion and cell cycle of the gastric cancer line MKN45 and gastric cell line...

Stomach cancer carcinomatosis peritonitis (SCCP) is a recalcitrant disease. The goal of the present study was to establish an in vitro-in vivo-like imageable model of SCCP to develop cell-cycle-based therapeutics of SCCP. We established 3-D Gelfoam® histoculture and tumor-sphere models of SCCP. FUCCI-expressing MKN-45 stomach cancer cells were transferred to express the fluorescence ubiquinized...

miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisted of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two...

We present a solution to the problem of performing approximate pattern matching on compressed text. The format we choose is the Ziv-Lempel family, speciically the LZ78 and LZW variants. Given a text of length u compressed into length n, and a pattern of length m, we report all the R occurrences of the pattern in the text allowing up to k insertions, deletions and substitutions, in O(mkn + R) ti...

We discuss the results of modelling the TeV γ-ray spectra of two AGNs, Mkn 501 and Mkn 421 that have almost the same redshifts: z = 0.031 and z = 0.034, respectively. The effect of intergalactic γ-ray absorption is treated as an uncertainty in the measurement of the intrinsic spectrum. Although the objects differ, we obtain satisfactory fits for both of them in a synchrotron self-Compton scenar...

Mkn 421 was observed by Chandra twice, on November 5, 1999 as part of the Chandra calibration program, with the ACIS-HETG configuration, and on May 29, 2000 following our Target Of Opportunity request aimed to catch the source in an ultra-high state, with both the ACIS-HETG and the HRC-LETG configurations. In this contribution we present and compare the two Chandra-MEG observations of Mkn 421, ...