ABSORPTION AND RELEASE OF MITOMYCIN-C BY “SPONGOSTAN FILM”. LARROSA JMl, FERRER J2, PINILLA 11, POLO VI, SANCHEZ Al, BUENO J’, HONRUBIA FMl. 1 Department of Ophthalmology, “Miguel Set-vet” Hospital. Zaragoza,(Spain) 2 Department of Microbiology, Puroose: To determine the Mitomycin-C (MMC) 0,4 mg./ml. absorption of spumous specimens of “Spongostan Film” (“Sp”) and their liberation rate. Methods:...

Background: Lymphocytes of Fanconi anemia (FA) show an increased sensitivity to the alkylating agents such as mitomycin C (MMC), but their responses to gamma-irradiation is controversial. The extent of DNA damage in leukocytes of FA patients following irradiation and MMC treatment was studied at cellular and single chromosome level. Methods: DNA damage induced by gamma-rays and MMC was measure...

ABSORPTION AND RELEASE OF MITOMYCIN-C BY “SPONGOSTAN FILM”. LARROSA JMl, FERRER J2, PINILLA 11, POLO VI, SANCHEZ Al, BUENO J’, HONRUBIA FMl. 1 Department of Ophthalmology, “Miguel Set-vet” Hospital. Zaragoza,(Spain) 2 Department of Microbiology, Puroose: To determine the Mitomycin-C (MMC) 0,4 mg./ml. absorption of spumous specimens of “Spongostan Film” (“Sp”) and their liberation rate. Methods:...

OBJECT Myelomeningocele (MMC) is the most severe form of spina bifida causing severe neurological deficits. Injury to the placode has been attributed to in utero aggression. In this study, glial and neuronal cell changes in both number and topography in mice with MMC were investigated during gestation. METHODS The curly tail/loop-tail mice model of MMC was used, and fetuses were harvested usi...

UNLABELLED Myelomeningocele (MMC)-commonly known as spina bifida-is a congenital birth defect that causes lifelong paralysis, incontinence, musculoskeletal deformities, and severe cognitive disabilities. The recent landmark Management of Myelomeningocele Study (MOMS) demonstrated for the first time in humans that in utero surgical repair of the MMC defect improves lower limb motor function, sug...

The aim of this investigation was to establish an appropriate tissue pharmacokinetic model to compare concentrations of mitomycin C (MMC) in the human bladder wall after either passive delivery or electromotive administration (EMDA) and to evaluate the effects of EMDA on tissue morphology and MMC structure. Tissue sections of human bladder were inserted into two chamber cells with urothelium ex...

In this paper predictive model for Metal Matrix Composite (MMCs) has been developed with the use of Artificial Neural Network. Stir casting process has been used to fabricate the fly ash based AL-6063 particulate MMC. The hardness of fly ash based AL-6063 MMC is taken as output variable, however fly ash(FA) percentage of reinforcement in MMC, stirring speed of stirrer and pouring temperature of...

The clinical practice of hyperthermic intraperitoneal chemoperfusion (HIPEC) for carcinomatosis has lacked preclinical justification. A standardized mouse model was created to evaluate the independent effects of intraperitoneal chemotherapy. Diffuse colorectal carcinomatosis was generated in mice prior to intraperitoneal lavage with mitomycin C (MMC) at clinically comparable dosing for variable...

Steinley and Brusco (2011) presented the results of a huge simulation study aimed at evaluating cluster recovery of mixture model clustering (MMC) both for the situation where the number of clusters is known and is unknown. They derived rather strong conclusions on the basis of this study, especially with regard to the good performance of K-means (KM) compared with MMC. I agree with the authors...

The Modular Multilevel Converter (MMC) topology is becoming an attractive solution for HVDC and FACTS systems. MMC structures are composed from several hundreds to thousands of half-bridge converters. Such large numbers of power switches and electrical nodes introduce important computational difficulties in electromagnetic transient (EMT) type programs. This becomes particularly more complex fo...