نتایج جستجو برای: mmtt
تعداد نتایج: 42 فیلتر نتایج به سال:
BACKGROUND Previous efforts to preserve β cell function in individuals with type 1 diabetes (T1D) have focused largely on the use of single immunomodulatory agents administered within 100 days of diagnosis. Based on human and preclinical studies, we hypothesized that a combination of low-dose anti-thymocyte globulin (ATG) and pegylated granulocyte CSF (G-CSF) would preserve β cell function in p...
OBJECTIVE To evaluate the extent of pancreatic β-cell function in a large number of insulin-dependent diabetic patients with a disease duration of 50 years or longer (Medalists). RESEARCH DESIGN AND METHODS Characterization of clinical and biochemical parameters and β-cell function of 411 Medalists with correlation with postmortem morphologic findings of 9 Medalists. RESULTS The Medalist co...
OBJECTIVE To examine the loss of glucagon response to hypoglycemia and its relationship with residual β-cell function early in the course of type 1 diabetes (T1D) in youth. RESEARCH DESIGN AND METHODS Twenty-one youth with T1D duration <1 year (ages 8-18 years, T1D duration 6-52 weeks) underwent mixed-meal tolerance tests (MMTTs) to assess residual β-cell function and hypoglycemic clamps to a...
Background/Objective: Individuals with a family history of type 1 diabetes mellitus (T1D) are at increased genetic risk for T1D. Previous studies identified the presence β-cell dysfunction before clinical onset and diagnosis However, it is unclear if predates islet autoimmunity in individuals high risk. Our objective was to test function antibody negative adults who have first-degree relative W...
Low-dose antithymocyte globulin (ATG) plus pegylated granulocyte colony-stimulating factor (G-CSF) preserves β-cell function for at least 12 months in type 1 diabetes. Herein, we describe metabolic and immunological parameters 24 months following treatment. Patients with established type 1 diabetes (duration 4-24 months) were randomized to ATG and pegylated G-CSF (ATG+G-CSF) (N = 17) or placebo...
C affeine is a widely used drug despite evidence that it has deleterious consequences for health, including diabetes (1). In 1967, a study reported that drinking two cups of instant coffee significantly impaired glucose tolerance in a small group of men with “maturity-onset diabetes” (2). Recent studies showed that caffeine acutely decreased insulin sensitivity in young, nondiabetic adults (3–5...
OBJECTIVE To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2). Twenty nondiabetic (ND) control children were also studi...
روش انتخابی و حساس برای تعیین کادمیم و روی ارائه شده است. این روش بر اساس تجمع جذب مجتمع های یون Cd (II) و Zn (II) با 4-آمینو-5-متیل-2،4-دی هیدرو-3H-1،2،4-تریاازول 3 ( MMTT) بر روی حلق آویز الکترودهای افت فشار جیوه (HMDE)، و سپس کاهش میزان جذب شده توسط اسکن ولتاژ با استفاده از مدولاسیون پالس دیفرانسیل. غلظت لیگاند، pH، پتانسیل و زمان انباشت، سرعت اسکن و ارتفاع پالس بهینه سازی شد. در شرایط بهینه...
Background Type 1 diabetes is characterised by progressive loss of functional β-cell mass, necessitating insulin treatment. We aimed to investigate the hypothesis that combining anti-interleukin (IL)-21 antibody (for low-grade and transient immunomodulation) with liraglutide (to improve function) could enable survival a reduced risk complications compared traditional immunomodulation. Methods T...
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