نتایج جستجو برای: montelukast sodium
تعداد نتایج: 188621 فیلتر نتایج به سال:
Montelukast sodium [1-([(1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)- ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio]methyl)cyclopropylacetic acid sodium salt] (MK-476, Singulair) is a potent and selective antagonist of the cysteinyl leukotriene (Cys-LT1) receptor and is under investigation for the treatment of bronchial asthma. To assess the metabolism and excretion of montelukast...
Montelukast sodium is a leukotriene inhibitor, and competitively antagonizes cys-LT1 receptor and used widely and effectively in treating allergic rhinitis, bronchial asthma and allied respiratory conditions. This case report outlines a rare case of montelukast induced hypercholesterolemia, severe hypertriglyceridemia and acute pancreatitis in a 22 years old male patient. The patient was taking...
Eosinophilic cystitis is a rare inflammatory disease with controversial aetiology and treatment. We report the case of a 61-year-old man presented with lower quadrant abdominal pain and lower urinary tract symptoms, non responsive to antibiotics and nonsteroidal antiinflammatory drugs. Physical examination was substantially negative, such as laboratory parameters, microscopic, bacteriological a...
Inflammatory process contributes to progressive lung tissue damage in cystic fibrosis (CF). Cysteinyl leukotrienes have been found in the sputum of CF patients at concentrations sufficient to cause potent biological effect. This study was designed to assess the effect of anti-inflammatory treatment with montelukast sodium in CF patients. Twelve patients, aged 6-29 were recruited. It was 20 week...
BACKGROUND Sulfur dioxide (SO(2)) gas may induce acute asthmatic responses when inhaled by individuals in the setting of community or occupational air pollution during exercise. Some asthma medications mitigate the SO(2) response, which is not fully understood but appears to involve multiple mechanisms. OBJECTIVE We tested the hypothesis that pretreatment with the cysteinyl-leukotriene inhibi...
This study includes determination Montelukast sodium by using flow injection chemiluminescence technique, the optimum concentrations were (150) ppm of magnesum ion, (5×10-4) M luminol, (0.001) hydrogen peroxide, linearity concetraction (0.1-0.001) that give highest luminescence intensity, and correlation cofficient was (0.9054), The relative standard deviation RSD% (2.3) detection limit (0.0001...
Background: The concept of formulating ODT containing montelukast sodium offers an appropriate, practical approach to accomplish fast release the drug. Absorption these tablets takes place directly into systemic circulation which bipass hepatic first-pass metabolism ultimately results in improvement bioavailability.
 Method: In present study were prepared by using different Superdisintegra...
OBJECTIVE Montelukast, a selective antagonist of Type 1 cysteinyl leukotriene receptors (CysLT1Rs), antagonizes the proinflammatory and proasthmatic activities of CysLT1Rs. We investigated the effect of montelukast on a surgically induced endometriosis rat model. STUDY DESIGN Thirty-two sexually mature, cycling, female Wistar-Albino rats, in which endometriotic implants were surgically induce...
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